<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2024 Workiva-->
<!--r:cf7a5cd3-29a2-4a95-9151-12e815010efd,g:56f85f5e-f590-46df-ae25-8a4771aeed0d-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.springworkstx.com/role/ConsolidatedStatementofStockholdersEquity" xlink:type="simple" xlink:href="swtx-20231231.xsd#ConsolidatedStatementofStockholdersEquity"/>
  <link:definitionLink xlink:role="http://www.springworkstx.com/role/ConsolidatedStatementofStockholdersEquity" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_41cc36c9-d47f-4b4f-ba9a-bc14bf60f11c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_4903d404-81f0-417e-8cf9-09cd877648dc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_41cc36c9-d47f-4b4f-ba9a-bc14bf60f11c" xlink:to="loc_us-gaap_StatementTable_4903d404-81f0-417e-8cf9-09cd877648dc" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_f400835f-eeba-469c-ae99-2cb9fcf023f6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_4903d404-81f0-417e-8cf9-09cd877648dc" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_f400835f-eeba-469c-ae99-2cb9fcf023f6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_f400835f-eeba-469c-ae99-2cb9fcf023f6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_f400835f-eeba-469c-ae99-2cb9fcf023f6" xlink:to="loc_us-gaap_EquityComponentDomain_f400835f-eeba-469c-ae99-2cb9fcf023f6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_16db3b99-fcfa-43b5-8c6e-9b6dd42ef438" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_f400835f-eeba-469c-ae99-2cb9fcf023f6" xlink:to="loc_us-gaap_EquityComponentDomain_16db3b99-fcfa-43b5-8c6e-9b6dd42ef438" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_98767651-ecf4-4c31-8ebd-6044ab42bea0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_16db3b99-fcfa-43b5-8c6e-9b6dd42ef438" xlink:to="loc_us-gaap_CommonStockMember_98767651-ecf4-4c31-8ebd-6044ab42bea0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonMember_eb0af217-cd5e-4a83-9a30-1d70dd0ab652" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TreasuryStockCommonMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_16db3b99-fcfa-43b5-8c6e-9b6dd42ef438" xlink:to="loc_us-gaap_TreasuryStockCommonMember_eb0af217-cd5e-4a83-9a30-1d70dd0ab652" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_ec6634c9-69b1-476b-bd1c-2f8391795f02" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_16db3b99-fcfa-43b5-8c6e-9b6dd42ef438" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_ec6634c9-69b1-476b-bd1c-2f8391795f02" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_d9e576ec-fa8a-4af5-b3e2-b73ab2d4b8c4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_16db3b99-fcfa-43b5-8c6e-9b6dd42ef438" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_d9e576ec-fa8a-4af5-b3e2-b73ab2d4b8c4" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_2da44ba7-9080-417d-bd2e-23c5c993cbe3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_16db3b99-fcfa-43b5-8c6e-9b6dd42ef438" xlink:to="loc_us-gaap_RetainedEarningsMember_2da44ba7-9080-417d-bd2e-23c5c993cbe3" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_919fa583-df02-4a72-aa71-54c39981cc7f" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_4903d404-81f0-417e-8cf9-09cd877648dc" xlink:to="loc_srt_CounterpartyNameAxis_919fa583-df02-4a72-aa71-54c39981cc7f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_919fa583-df02-4a72-aa71-54c39981cc7f_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_919fa583-df02-4a72-aa71-54c39981cc7f" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_919fa583-df02-4a72-aa71-54c39981cc7f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_e97d4b9c-a26d-41fe-80eb-794ec4b9e90c" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_919fa583-df02-4a72-aa71-54c39981cc7f" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_e97d4b9c-a26d-41fe-80eb-794ec4b9e90c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_GSKMember_a07f96f1-de8a-40d7-b7b8-f772a1aaba9d" xlink:href="swtx-20231231.xsd#swtx_GSKMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_e97d4b9c-a26d-41fe-80eb-794ec4b9e90c" xlink:to="loc_swtx_GSKMember_a07f96f1-de8a-40d7-b7b8-f772a1aaba9d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_b4b4f7fa-0180-4cba-bba0-2a5a90efea56" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_4903d404-81f0-417e-8cf9-09cd877648dc" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_b4b4f7fa-0180-4cba-bba0-2a5a90efea56" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_b4b4f7fa-0180-4cba-bba0-2a5a90efea56_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_b4b4f7fa-0180-4cba-bba0-2a5a90efea56" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_b4b4f7fa-0180-4cba-bba0-2a5a90efea56_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_91ccb593-25d8-45ac-9a66-a5fb3ce68166" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_b4b4f7fa-0180-4cba-bba0-2a5a90efea56" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_91ccb593-25d8-45ac-9a66-a5fb3ce68166" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrivatePlacementMember_170df5a5-3d04-4044-a6bc-658c33663579" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PrivatePlacementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_91ccb593-25d8-45ac-9a66-a5fb3ce68166" xlink:to="loc_us-gaap_PrivatePlacementMember_170df5a5-3d04-4044-a6bc-658c33663579" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_MarketOfferingMember_1a3717f4-29a0-47b2-b0a9-931d59c8ef40" xlink:href="swtx-20231231.xsd#swtx_MarketOfferingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_91ccb593-25d8-45ac-9a66-a5fb3ce68166" xlink:to="loc_swtx_MarketOfferingMember_1a3717f4-29a0-47b2-b0a9-931d59c8ef40" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_UnderwrittenPublicOfferingMember_a030eb22-d7d7-4204-9aa5-5f55a22b483d" xlink:href="swtx-20231231.xsd#swtx_UnderwrittenPublicOfferingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_91ccb593-25d8-45ac-9a66-a5fb3ce68166" xlink:to="loc_swtx_UnderwrittenPublicOfferingMember_a030eb22-d7d7-4204-9aa5-5f55a22b483d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1b04a3aa-c4f3-43f1-a43f-ca28e3d4f9ab" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_41cc36c9-d47f-4b4f-ba9a-bc14bf60f11c" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1b04a3aa-c4f3-43f1-a43f-ca28e3d4f9ab" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_ebb0e082-fb77-419c-9d84-ea8e98b3d532" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1b04a3aa-c4f3-43f1-a43f-ca28e3d4f9ab" xlink:to="loc_us-gaap_StockholdersEquity_ebb0e082-fb77-419c-9d84-ea8e98b3d532" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_c8455766-0074-44bf-bce4-175296f35b3a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1b04a3aa-c4f3-43f1-a43f-ca28e3d4f9ab" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_c8455766-0074-44bf-bce4-175296f35b3a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonShares_c82d9e4f-5ee5-4267-bee1-af81ba88fa8c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TreasuryStockCommonShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1b04a3aa-c4f3-43f1-a43f-ca28e3d4f9ab" xlink:to="loc_us-gaap_TreasuryStockCommonShares_c82d9e4f-5ee5-4267-bee1-af81ba88fa8c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_111c36cf-4bf1-4bb8-bf51-078bb1cf5c05" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1b04a3aa-c4f3-43f1-a43f-ca28e3d4f9ab" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_111c36cf-4bf1-4bb8-bf51-078bb1cf5c05" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_c78ba241-891c-4ba9-b3e8-d7aab59bcab0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1b04a3aa-c4f3-43f1-a43f-ca28e3d4f9ab" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_c78ba241-891c-4ba9-b3e8-d7aab59bcab0" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_585b1dc7-7786-40f8-b269-420d8a1a95a3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1b04a3aa-c4f3-43f1-a43f-ca28e3d4f9ab" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_585b1dc7-7786-40f8-b269-420d8a1a95a3" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardGross_665a3bba-f99c-49fd-a21e-89abcffbf24b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1b04a3aa-c4f3-43f1-a43f-ca28e3d4f9ab" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardGross_665a3bba-f99c-49fd-a21e-89abcffbf24b" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardForfeited_4b0169fe-6c25-4c90-8a45-bf79c83b0317" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardForfeited"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1b04a3aa-c4f3-43f1-a43f-ca28e3d4f9ab" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardForfeited_4b0169fe-6c25-4c90-8a45-bf79c83b0317" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_e864c7df-173c-479a-9574-d05bff04500d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1b04a3aa-c4f3-43f1-a43f-ca28e3d4f9ab" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_e864c7df-173c-479a-9574-d05bff04500d" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_b533b3bd-8251-4894-a52d-42b852ac8e7e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1b04a3aa-c4f3-43f1-a43f-ca28e3d4f9ab" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_b533b3bd-8251-4894-a52d-42b852ac8e7e" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_173047a4-dbcc-443a-8223-cf13270a3867" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1b04a3aa-c4f3-43f1-a43f-ca28e3d4f9ab" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_173047a4-dbcc-443a-8223-cf13270a3867" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation_c47b9ae7-5128-46dc-9d6e-eaeb357c7890" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1b04a3aa-c4f3-43f1-a43f-ca28e3d4f9ab" xlink:to="loc_us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation_c47b9ae7-5128-46dc-9d6e-eaeb357c7890" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesPaidForTaxWithholdingForShareBasedCompensation_b2590eeb-3915-416c-af50-960b7ff9b267" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SharesPaidForTaxWithholdingForShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1b04a3aa-c4f3-43f1-a43f-ca28e3d4f9ab" xlink:to="loc_us-gaap_SharesPaidForTaxWithholdingForShareBasedCompensation_b2590eeb-3915-416c-af50-960b7ff9b267" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_c8f28be9-a9b6-471f-94ab-d855c12b5a10" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1b04a3aa-c4f3-43f1-a43f-ca28e3d4f9ab" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_c8f28be9-a9b6-471f-94ab-d855c12b5a10" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_b1c40e84-16db-4064-9f57-1d252bda9e52" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1b04a3aa-c4f3-43f1-a43f-ca28e3d4f9ab" xlink:to="loc_us-gaap_NetIncomeLoss_b1c40e84-16db-4064-9f57-1d252bda9e52" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_65cd3abb-5650-4cf0-b451-3e010c472993" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_ad070595-86df-4aa3-94c0-7b6a0d218c5f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonShares_0f703e9d-276c-4381-8272-57109a921060" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TreasuryStockCommonShares"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.springworkstx.com/role/ConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="swtx-20231231.xsd#ConsolidatedStatementsofCashFlows"/>
  <link:definitionLink xlink:role="http://www.springworkstx.com/role/ConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_fcb7cd0d-e7de-4efa-98fe-d12bb25d4135" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_61c43da4-f9a9-49c7-a5e1-7ec0951e3adc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_fcb7cd0d-e7de-4efa-98fe-d12bb25d4135" xlink:to="loc_us-gaap_StatementTable_61c43da4-f9a9-49c7-a5e1-7ec0951e3adc" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_96966579-e637-451b-a476-3faa25d0cd79" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_61c43da4-f9a9-49c7-a5e1-7ec0951e3adc" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_96966579-e637-451b-a476-3faa25d0cd79" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_96966579-e637-451b-a476-3faa25d0cd79_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_96966579-e637-451b-a476-3faa25d0cd79" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_96966579-e637-451b-a476-3faa25d0cd79_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_b11e3e2c-8f70-4a95-a5a6-0e5385aaf6bf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_96966579-e637-451b-a476-3faa25d0cd79" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_b11e3e2c-8f70-4a95-a5a6-0e5385aaf6bf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_GSKMember_30000df4-6385-4fc0-b7c2-4dcee1da969c" xlink:href="swtx-20231231.xsd#swtx_GSKMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_b11e3e2c-8f70-4a95-a5a6-0e5385aaf6bf" xlink:to="loc_swtx_GSKMember_30000df4-6385-4fc0-b7c2-4dcee1da969c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrivatePlacementMember_c7eba141-e680-4a21-85cd-bc722daa2c89" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PrivatePlacementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_b11e3e2c-8f70-4a95-a5a6-0e5385aaf6bf" xlink:to="loc_us-gaap_PrivatePlacementMember_c7eba141-e680-4a21-85cd-bc722daa2c89" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_MarketOfferingMember_24acde13-891d-4537-9cda-e848e60d8ab6" xlink:href="swtx-20231231.xsd#swtx_MarketOfferingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_b11e3e2c-8f70-4a95-a5a6-0e5385aaf6bf" xlink:to="loc_swtx_MarketOfferingMember_24acde13-891d-4537-9cda-e848e60d8ab6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_4359e44e-f812-4af1-808d-2d253de4cf57" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementOfCashFlowsAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_fcb7cd0d-e7de-4efa-98fe-d12bb25d4135" xlink:to="loc_us-gaap_StatementOfCashFlowsAbstract_4359e44e-f812-4af1-808d-2d253de4cf57" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_57b55a50-ae1b-4ed9-a1aa-aa8983250675" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_4359e44e-f812-4af1-808d-2d253de4cf57" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_57b55a50-ae1b-4ed9-a1aa-aa8983250675" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_53510e6a-26b2-446f-a6c4-2e504db318fc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_57b55a50-ae1b-4ed9-a1aa-aa8983250675" xlink:to="loc_us-gaap_NetIncomeLoss_53510e6a-26b2-446f-a6c4-2e504db318fc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_5c5c30e1-7e9c-427d-bb1c-b23cdb583824" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_57b55a50-ae1b-4ed9-a1aa-aa8983250675" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_5c5c30e1-7e9c-427d-bb1c-b23cdb583824" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_b49bb296-b36f-49e9-8acf-2108372300eb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_5c5c30e1-7e9c-427d-bb1c-b23cdb583824" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_b49bb296-b36f-49e9-8acf-2108372300eb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_NonCashOperatingLeaseExpense_35f58f24-51cd-4d7e-9a4e-063ca91428ec" xlink:href="swtx-20231231.xsd#swtx_NonCashOperatingLeaseExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_5c5c30e1-7e9c-427d-bb1c-b23cdb583824" xlink:to="loc_swtx_NonCashOperatingLeaseExpense_35f58f24-51cd-4d7e-9a4e-063ca91428ec" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_9814a554-049a-461d-9fd3-ab8bf222ff44" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_5c5c30e1-7e9c-427d-bb1c-b23cdb583824" xlink:to="loc_us-gaap_ShareBasedCompensation_9814a554-049a-461d-9fd3-ab8bf222ff44" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_ce81a2fb-98ff-4d21-a186-8743903ea95b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromEquityMethodInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_5c5c30e1-7e9c-427d-bb1c-b23cdb583824" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_ce81a2fb-98ff-4d21-a186-8743903ea95b" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingAssetsAbstract_bbf6956b-3ead-469a-8e9a-baab894042e6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInOperatingAssetsAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_57b55a50-ae1b-4ed9-a1aa-aa8983250675" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingAssetsAbstract_bbf6956b-3ead-469a-8e9a-baab894042e6" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_551c7481-54ea-4747-9140-4d4053924b03" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingAssetsAbstract_bbf6956b-3ead-469a-8e9a-baab894042e6" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_551c7481-54ea-4747-9140-4d4053924b03" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_affc420c-01b5-4a6d-b3dc-40c6b5481b18" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingAssetsAbstract_bbf6956b-3ead-469a-8e9a-baab894042e6" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_affc420c-01b5-4a6d-b3dc-40c6b5481b18" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_90b7808a-46bc-4065-acc0-e7e7b3da28e9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingAssetsAbstract_bbf6956b-3ead-469a-8e9a-baab894042e6" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_90b7808a-46bc-4065-acc0-e7e7b3da28e9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherCurrentAssets_aad9f0ca-2bed-46ea-a592-ad7da869c3e4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInOtherCurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingAssetsAbstract_bbf6956b-3ead-469a-8e9a-baab894042e6" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherCurrentAssets_aad9f0ca-2bed-46ea-a592-ad7da869c3e4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_95cea418-5f78-4355-b504-a490d0d0e07e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingAssetsAbstract_bbf6956b-3ead-469a-8e9a-baab894042e6" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_95cea418-5f78-4355-b504-a490d0d0e07e" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_a9d7efe3-50cf-44c1-a562-828524395d3e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingAssetsAbstract_bbf6956b-3ead-469a-8e9a-baab894042e6" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_a9d7efe3-50cf-44c1-a562-828524395d3e" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_IncreaseDecreaseInLeaseLiability_1c65fbbd-785a-4048-b33b-af46b6ccf1a0" xlink:href="swtx-20231231.xsd#swtx_IncreaseDecreaseInLeaseLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingAssetsAbstract_bbf6956b-3ead-469a-8e9a-baab894042e6" xlink:to="loc_swtx_IncreaseDecreaseInLeaseLiability_1c65fbbd-785a-4048-b33b-af46b6ccf1a0" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_696fc7ed-058c-4ed6-b28a-89805758a5da" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingAssetsAbstract_bbf6956b-3ead-469a-8e9a-baab894042e6" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_696fc7ed-058c-4ed6-b28a-89805758a5da" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_dade84d8-7c6a-48bd-a469-5d6f07adc645" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInOtherOperatingLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingAssetsAbstract_bbf6956b-3ead-469a-8e9a-baab894042e6" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_dade84d8-7c6a-48bd-a469-5d6f07adc645" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b6b0499f-264b-4e7a-990b-30c63032b59f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_57b55a50-ae1b-4ed9-a1aa-aa8983250675" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b6b0499f-264b-4e7a-990b-30c63032b59f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_c44ff640-2b14-4c98-8932-fff804ebd731" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_4359e44e-f812-4af1-808d-2d253de4cf57" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_c44ff640-2b14-4c98-8932-fff804ebd731" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_584a68e1-bb63-45e5-ac79-c9029dfaa912" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_c44ff640-2b14-4c98-8932-fff804ebd731" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_584a68e1-bb63-45e5-ac79-c9029dfaa912" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireEquityMethodInvestments_36290a03-1865-4a54-b952-a6c3798c595c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquireEquityMethodInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_c44ff640-2b14-4c98-8932-fff804ebd731" xlink:to="loc_us-gaap_PaymentsToAcquireEquityMethodInvestments_36290a03-1865-4a54-b952-a6c3798c595c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_02bcbf75-4755-433e-b1d6-225f0c764f6b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquireMarketableSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_c44ff640-2b14-4c98-8932-fff804ebd731" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_02bcbf75-4755-433e-b1d6-225f0c764f6b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_6acc3c29-2e3e-4a6c-95b4-007a3b02f01a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_c44ff640-2b14-4c98-8932-fff804ebd731" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_6acc3c29-2e3e-4a6c-95b4-007a3b02f01a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_fac3a293-9508-4e84-b2e9-52d02e3dccb2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_c44ff640-2b14-4c98-8932-fff804ebd731" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_fac3a293-9508-4e84-b2e9-52d02e3dccb2" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_921af13b-2517-4369-8167-5ee48be50353" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_4359e44e-f812-4af1-808d-2d253de4cf57" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_921af13b-2517-4369-8167-5ee48be50353" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_8ef47edc-2f55-479a-8004-4d471e639766" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_921af13b-2517-4369-8167-5ee48be50353" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_8ef47edc-2f55-479a-8004-4d471e639766" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfPrivatePlacement_4c8dc618-ccb1-464e-bce7-afc064b379d9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromIssuanceOfPrivatePlacement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_921af13b-2517-4369-8167-5ee48be50353" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfPrivatePlacement_4c8dc618-ccb1-464e-bce7-afc064b379d9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_9e2a2aba-f1e7-41be-8200-af7d6b1a9cbf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_921af13b-2517-4369-8167-5ee48be50353" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_9e2a2aba-f1e7-41be-8200-af7d6b1a9cbf" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_81885d91-89d3-408c-9e93-d4a34f3af927" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_921af13b-2517-4369-8167-5ee48be50353" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_81885d91-89d3-408c-9e93-d4a34f3af927" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_aa9bf1fa-b1c9-4afd-933c-5bc34a1bc399" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_921af13b-2517-4369-8167-5ee48be50353" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_aa9bf1fa-b1c9-4afd-933c-5bc34a1bc399" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_b3470bb6-b494-402e-867b-5e7557afadee" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_4359e44e-f812-4af1-808d-2d253de4cf57" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_b3470bb6-b494-402e-867b-5e7557afadee" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_0547d627-e2af-4d23-9463-8af8e9520419" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_4359e44e-f812-4af1-808d-2d253de4cf57" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_0547d627-e2af-4d23-9463-8af8e9520419" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_b8ae5925-e31f-4c8d-9114-73618ff66900" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SupplementalCashFlowInformationAbstract_10405844-7de7-41f0-b7ab-a4a0fed65cd5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SupplementalCashFlowInformationAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_4359e44e-f812-4af1-808d-2d253de4cf57" xlink:to="loc_us-gaap_SupplementalCashFlowInformationAbstract_10405844-7de7-41f0-b7ab-a4a0fed65cd5" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability_de0e8824-e1f8-41fe-96df-69d1f3a4984e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_10405844-7de7-41f0-b7ab-a4a0fed65cd5" xlink:to="loc_us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability_de0e8824-e1f8-41fe-96df-69d1f3a4984e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_MilestonePaymentForFirstCommercialSaleIncludedInAccruedExpenses_58e02394-8b72-44bf-88d0-f6fffec6d93a" xlink:href="swtx-20231231.xsd#swtx_MilestonePaymentForFirstCommercialSaleIncludedInAccruedExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_10405844-7de7-41f0-b7ab-a4a0fed65cd5" xlink:to="loc_swtx_MilestonePaymentForFirstCommercialSaleIncludedInAccruedExpenses_58e02394-8b72-44bf-88d0-f6fffec6d93a" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.springworkstx.com/role/NatureofOperationsDetails" xlink:type="simple" xlink:href="swtx-20231231.xsd#NatureofOperationsDetails"/>
  <link:definitionLink xlink:role="http://www.springworkstx.com/role/NatureofOperationsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_a157e0bd-ea8c-4906-b49a-bd0972782bee" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_12ee13c0-8650-4656-9da9-12b474476ea6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_a157e0bd-ea8c-4906-b49a-bd0972782bee" xlink:to="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_12ee13c0-8650-4656-9da9-12b474476ea6" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_835035dd-3e34-47dd-ad7a-2970d9d93199" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_12ee13c0-8650-4656-9da9-12b474476ea6" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_835035dd-3e34-47dd-ad7a-2970d9d93199" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_835035dd-3e34-47dd-ad7a-2970d9d93199_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_835035dd-3e34-47dd-ad7a-2970d9d93199" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_835035dd-3e34-47dd-ad7a-2970d9d93199_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_2efce703-7d23-4371-a73f-7442af0fb2c0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_835035dd-3e34-47dd-ad7a-2970d9d93199" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_2efce703-7d23-4371-a73f-7442af0fb2c0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_FollowOnOfferingMember_b3226307-7a95-460a-aced-5a53c950f385" xlink:href="swtx-20231231.xsd#swtx_FollowOnOfferingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_2efce703-7d23-4371-a73f-7442af0fb2c0" xlink:to="loc_swtx_FollowOnOfferingMember_b3226307-7a95-460a-aced-5a53c950f385" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OverAllotmentOptionMember_e5f78fa1-3c2b-45c3-8740-20db109d809f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OverAllotmentOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_2efce703-7d23-4371-a73f-7442af0fb2c0" xlink:to="loc_us-gaap_OverAllotmentOptionMember_e5f78fa1-3c2b-45c3-8740-20db109d809f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrivatePlacementMember_4d2ea8c2-89f9-43bd-b164-760aab17da98" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PrivatePlacementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_2efce703-7d23-4371-a73f-7442af0fb2c0" xlink:to="loc_us-gaap_PrivatePlacementMember_4d2ea8c2-89f9-43bd-b164-760aab17da98" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_AtTheMarketOfferingMember_11167e9b-5360-450b-8167-a27c24f969ea" xlink:href="swtx-20231231.xsd#swtx_AtTheMarketOfferingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_2efce703-7d23-4371-a73f-7442af0fb2c0" xlink:to="loc_swtx_AtTheMarketOfferingMember_11167e9b-5360-450b-8167-a27c24f969ea" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_7bb20a64-1d3d-48b8-af40-e040971f9b84" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_12ee13c0-8650-4656-9da9-12b474476ea6" xlink:to="loc_srt_CounterpartyNameAxis_7bb20a64-1d3d-48b8-af40-e040971f9b84" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_7bb20a64-1d3d-48b8-af40-e040971f9b84_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_7bb20a64-1d3d-48b8-af40-e040971f9b84" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_7bb20a64-1d3d-48b8-af40-e040971f9b84_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_60b09128-cdc3-4ba4-8d68-a8697628e86b" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_7bb20a64-1d3d-48b8-af40-e040971f9b84" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_60b09128-cdc3-4ba4-8d68-a8697628e86b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_GSKMember_df80c38e-e410-4bdb-a364-20eb50e37d29" xlink:href="swtx-20231231.xsd#swtx_GSKMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_60b09128-cdc3-4ba4-8d68-a8697628e86b" xlink:to="loc_swtx_GSKMember_df80c38e-e410-4bdb-a364-20eb50e37d29" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_CowenAndCompanyLLCMember_7844984c-4748-4dee-aae2-6ced1baac168" xlink:href="swtx-20231231.xsd#swtx_CowenAndCompanyLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_60b09128-cdc3-4ba4-8d68-a8697628e86b" xlink:to="loc_swtx_CowenAndCompanyLLCMember_7844984c-4748-4dee-aae2-6ced1baac168" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_31a66e82-7c80-4db8-b2a6-21cf0bbd3708" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_a157e0bd-ea8c-4906-b49a-bd0972782bee" xlink:to="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_31a66e82-7c80-4db8-b2a6-21cf0bbd3708" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_84f75ec9-7a32-4ec9-b318-46470b9144fe" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SaleOfStockPricePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_a157e0bd-ea8c-4906-b49a-bd0972782bee" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_84f75ec9-7a32-4ec9-b318-46470b9144fe" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_61bc8d6b-2d1d-45d2-8912-aa46ebb66ea5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SaleOfStockConsiderationReceivedOnTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_a157e0bd-ea8c-4906-b49a-bd0972782bee" xlink:to="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_61bc8d6b-2d1d-45d2-8912-aa46ebb66ea5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_SaleOfStockConsiderationReceivedOnTransactionGrossProceeds_3db3c44f-f4ce-444e-95f4-a92604be3a43" xlink:href="swtx-20231231.xsd#swtx_SaleOfStockConsiderationReceivedOnTransactionGrossProceeds"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_a157e0bd-ea8c-4906-b49a-bd0972782bee" xlink:to="loc_swtx_SaleOfStockConsiderationReceivedOnTransactionGrossProceeds_3db3c44f-f4ce-444e-95f4-a92604be3a43" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_SaleOfStockPricePremiumRate_a5a9eeb4-316c-4013-9080-66fc4ceb9c6a" xlink:href="swtx-20231231.xsd#swtx_SaleOfStockPricePremiumRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_a157e0bd-ea8c-4906-b49a-bd0972782bee" xlink:to="loc_swtx_SaleOfStockPricePremiumRate_a5a9eeb4-316c-4013-9080-66fc4ceb9c6a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_SalesOfStockPremiumTerm_bb1795a3-2877-42c6-99f0-35e9a15a6f30" xlink:href="swtx-20231231.xsd#swtx_SalesOfStockPremiumTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_a157e0bd-ea8c-4906-b49a-bd0972782bee" xlink:to="loc_swtx_SalesOfStockPremiumTerm_bb1795a3-2877-42c6-99f0-35e9a15a6f30" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_SaleOfStockCommissionFee_61e95008-dbd1-4778-9412-7c4cfb9adff9" xlink:href="swtx-20231231.xsd#swtx_SaleOfStockCommissionFee"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_a157e0bd-ea8c-4906-b49a-bd0972782bee" xlink:to="loc_swtx_SaleOfStockCommissionFee_61e95008-dbd1-4778-9412-7c4cfb9adff9" xlink:type="arc" order="6"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.springworkstx.com/role/RisksandLiquidityDetails" xlink:type="simple" xlink:href="swtx-20231231.xsd#RisksandLiquidityDetails"/>
  <link:definitionLink xlink:role="http://www.springworkstx.com/role/RisksandLiquidityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskLineItems_dff3f786-de01-4e22-8f66-0a826558cd40" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTable_8875b2e9-402e-45a7-b9f9-4c28a44d3ee6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_dff3f786-de01-4e22-8f66-0a826558cd40" xlink:to="loc_us-gaap_ConcentrationRiskTable_8875b2e9-402e-45a7-b9f9-4c28a44d3ee6" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_c83d1e18-db73-444d-b4eb-705d0c0b1a31" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_8875b2e9-402e-45a7-b9f9-4c28a44d3ee6" xlink:to="loc_srt_ProductOrServiceAxis_c83d1e18-db73-444d-b4eb-705d0c0b1a31" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_c83d1e18-db73-444d-b4eb-705d0c0b1a31_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_c83d1e18-db73-444d-b4eb-705d0c0b1a31" xlink:to="loc_srt_ProductsAndServicesDomain_c83d1e18-db73-444d-b4eb-705d0c0b1a31_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_70f9462b-5a58-4754-b1d6-43b72c181571" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_c83d1e18-db73-444d-b4eb-705d0c0b1a31" xlink:to="loc_srt_ProductsAndServicesDomain_70f9462b-5a58-4754-b1d6-43b72c181571" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_OGSIVEOMember_36c124e7-890f-4f86-af3c-5f8fa2b653a4" xlink:href="swtx-20231231.xsd#swtx_OGSIVEOMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_70f9462b-5a58-4754-b1d6-43b72c181571" xlink:to="loc_swtx_OGSIVEOMember_36c124e7-890f-4f86-af3c-5f8fa2b653a4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_d38d0f14-ce22-4c95-bd85-3ca3d37fa18a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_dff3f786-de01-4e22-8f66-0a826558cd40" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_d38d0f14-ce22-4c95-bd85-3ca3d37fa18a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_WorkingCapital_d600eef0-f5e6-4f9d-ac17-c4dbbbed3f8c" xlink:href="swtx-20231231.xsd#swtx_WorkingCapital"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_dff3f786-de01-4e22-8f66-0a826558cd40" xlink:to="loc_swtx_WorkingCapital_d600eef0-f5e6-4f9d-ac17-c4dbbbed3f8c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_1dc9ed38-d118-424d-bc40-10bc320cf50a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_dff3f786-de01-4e22-8f66-0a826558cd40" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_1dc9ed38-d118-424d-bc40-10bc320cf50a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_262f1aa7-c475-4a73-ab86-5263428c3b28" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashCashEquivalentsAndShortTermInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_dff3f786-de01-4e22-8f66-0a826558cd40" xlink:to="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_262f1aa7-c475-4a73-ab86-5263428c3b28" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.springworkstx.com/role/SummaryofSignificantAccountingPoliciesDetails" xlink:type="simple" xlink:href="swtx-20231231.xsd#SummaryofSignificantAccountingPoliciesDetails"/>
  <link:definitionLink xlink:role="http://www.springworkstx.com/role/SummaryofSignificantAccountingPoliciesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_611338c2-3848-40a8-b940-5600b7b218bd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_e38af468-c3ed-44c7-8599-7e32944477cc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_611338c2-3848-40a8-b940-5600b7b218bd" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_e38af468-c3ed-44c7-8599-7e32944477cc" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_f4e7ba24-d9c5-435c-b7b1-6d8408e31573" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_e38af468-c3ed-44c7-8599-7e32944477cc" xlink:to="loc_srt_RangeAxis_f4e7ba24-d9c5-435c-b7b1-6d8408e31573" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_f4e7ba24-d9c5-435c-b7b1-6d8408e31573_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_f4e7ba24-d9c5-435c-b7b1-6d8408e31573" xlink:to="loc_srt_RangeMember_f4e7ba24-d9c5-435c-b7b1-6d8408e31573_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_a0e20ae7-a44d-47c6-aec7-99e055235f58" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_f4e7ba24-d9c5-435c-b7b1-6d8408e31573" xlink:to="loc_srt_RangeMember_a0e20ae7-a44d-47c6-aec7-99e055235f58" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_ba2a7d0b-581d-4e52-8d23-6fc0f094829e" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_a0e20ae7-a44d-47c6-aec7-99e055235f58" xlink:to="loc_srt_MinimumMember_ba2a7d0b-581d-4e52-8d23-6fc0f094829e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_10842ae9-a301-432f-9bcd-f865b4d27310" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_a0e20ae7-a44d-47c6-aec7-99e055235f58" xlink:to="loc_srt_MaximumMember_10842ae9-a301-432f-9bcd-f865b4d27310" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfOperatingSegments_c5bad69a-0eb4-406f-9868-2e9b11a4df53" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NumberOfOperatingSegments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_611338c2-3848-40a8-b940-5600b7b218bd" xlink:to="loc_us-gaap_NumberOfOperatingSegments_c5bad69a-0eb4-406f-9868-2e9b11a4df53" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_29485419-90d8-475c-a611-2ce8d7b30267" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_611338c2-3848-40a8-b940-5600b7b218bd" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_29485419-90d8-475c-a611-2ce8d7b30267" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_3c55a4a7-d425-48ba-9177-b20cb3597416" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_611338c2-3848-40a8-b940-5600b7b218bd" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_3c55a4a7-d425-48ba-9177-b20cb3597416" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendPayments_1f3c0c18-8531-4e99-9316-05ed922945dc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendPayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_611338c2-3848-40a8-b940-5600b7b218bd" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendPayments_1f3c0c18-8531-4e99-9316-05ed922945dc" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.springworkstx.com/role/MarketableSecuritiesDetails" xlink:type="simple" xlink:href="swtx-20231231.xsd#MarketableSecuritiesDetails"/>
  <link:definitionLink xlink:role="http://www.springworkstx.com/role/MarketableSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesLineItems_e7c1f8e9-939f-46f0-9de7-b587b3255a46" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MarketableSecuritiesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesTable_ff2609bb-a007-4222-898a-d00a57197833" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MarketableSecuritiesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_e7c1f8e9-939f-46f0-9de7-b587b3255a46" xlink:to="loc_us-gaap_MarketableSecuritiesTable_ff2609bb-a007-4222-898a-d00a57197833" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_1b66ed48-cc36-406b-9bdd-d23da44263f8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_MarketableSecuritiesTable_ff2609bb-a007-4222-898a-d00a57197833" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_1b66ed48-cc36-406b-9bdd-d23da44263f8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_1b66ed48-cc36-406b-9bdd-d23da44263f8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_1b66ed48-cc36-406b-9bdd-d23da44263f8" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_1b66ed48-cc36-406b-9bdd-d23da44263f8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_ff0128b2-6d1d-4194-9947-661b04059ab3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_1b66ed48-cc36-406b-9bdd-d23da44263f8" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_ff0128b2-6d1d-4194-9947-661b04059ab3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestmentsMember_721b947e-7700-4297-b90c-a6d55ad52cbb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShortTermInvestmentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_ff0128b2-6d1d-4194-9947-661b04059ab3" xlink:to="loc_us-gaap_ShortTermInvestmentsMember_721b947e-7700-4297-b90c-a6d55ad52cbb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_LongTermInvestmentsMember_57e67770-85e1-4d84-891c-e91413580b99" xlink:href="swtx-20231231.xsd#swtx_LongTermInvestmentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_ff0128b2-6d1d-4194-9947-661b04059ab3" xlink:to="loc_swtx_LongTermInvestmentsMember_57e67770-85e1-4d84-891c-e91413580b99" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_b0147305-5ac5-495a-bb0f-a54fcc6095ee" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_MarketableSecuritiesTable_ff2609bb-a007-4222-898a-d00a57197833" xlink:to="loc_us-gaap_FinancialInstrumentAxis_b0147305-5ac5-495a-bb0f-a54fcc6095ee" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_b0147305-5ac5-495a-bb0f-a54fcc6095ee_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_b0147305-5ac5-495a-bb0f-a54fcc6095ee" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_b0147305-5ac5-495a-bb0f-a54fcc6095ee_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_15c1e0b7-5449-4b4c-b6e4-b830d94ce987" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_b0147305-5ac5-495a-bb0f-a54fcc6095ee" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_15c1e0b7-5449-4b4c-b6e4-b830d94ce987" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentDebtSecuritiesMember_398989ee-00d8-433f-be07-5ceb6fc38292" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_USGovernmentDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_15c1e0b7-5449-4b4c-b6e4-b830d94ce987" xlink:to="loc_us-gaap_USGovernmentDebtSecuritiesMember_398989ee-00d8-433f-be07-5ceb6fc38292" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignGovernmentDebtSecuritiesMember_cc3f2e7f-fc17-498e-9f4d-06b06252935f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ForeignGovernmentDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_15c1e0b7-5449-4b4c-b6e4-b830d94ce987" xlink:to="loc_us-gaap_ForeignGovernmentDebtSecuritiesMember_cc3f2e7f-fc17-498e-9f4d-06b06252935f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_03cf0da1-729f-44c6-939e-64792400ea66" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CorporateDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_15c1e0b7-5449-4b4c-b6e4-b830d94ce987" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_03cf0da1-729f-44c6-939e-64792400ea66" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_3690faf0-af12-488c-9477-0174c74bc156" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommercialPaperMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_15c1e0b7-5449-4b4c-b6e4-b830d94ce987" xlink:to="loc_us-gaap_CommercialPaperMember_3690faf0-af12-488c-9477-0174c74bc156" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_faa5b177-981d-4b5d-9070-f8f3965317a9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_e7c1f8e9-939f-46f0-9de7-b587b3255a46" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_faa5b177-981d-4b5d-9070-f8f3965317a9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_c73a81ef-1e3e-463f-9f01-a25ea604b8d3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_e7c1f8e9-939f-46f0-9de7-b587b3255a46" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_c73a81ef-1e3e-463f-9f01-a25ea604b8d3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_57239695-4df4-4866-a65a-d1b359ae026b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_e7c1f8e9-939f-46f0-9de7-b587b3255a46" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_57239695-4df4-4866-a65a-d1b359ae026b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_55bf8b66-4fc2-43b2-9d4d-098b9a3667b7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_e7c1f8e9-939f-46f0-9de7-b587b3255a46" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_55bf8b66-4fc2-43b2-9d4d-098b9a3667b7" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.springworkstx.com/role/FairValueMeasurementsDetails" xlink:type="simple" xlink:href="swtx-20231231.xsd#FairValueMeasurementsDetails"/>
  <link:definitionLink xlink:role="http://www.springworkstx.com/role/FairValueMeasurementsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_02429e57-13e8-4685-8af3-bbae98c9c947" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_06164ddd-3565-41d6-8801-b2e628c4821f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_02429e57-13e8-4685-8af3-bbae98c9c947" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_06164ddd-3565-41d6-8801-b2e628c4821f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_3ddfca2e-0d6a-419e-872c-cd5eb4ecc975" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_06164ddd-3565-41d6-8801-b2e628c4821f" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_3ddfca2e-0d6a-419e-872c-cd5eb4ecc975" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3ddfca2e-0d6a-419e-872c-cd5eb4ecc975_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_3ddfca2e-0d6a-419e-872c-cd5eb4ecc975" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3ddfca2e-0d6a-419e-872c-cd5eb4ecc975_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_26386cca-a582-46e8-aba9-04cb9624a7a3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_3ddfca2e-0d6a-419e-872c-cd5eb4ecc975" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_26386cca-a582-46e8-aba9-04cb9624a7a3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_2c21e0f2-7d93-49d4-b462-9eeab2679d7a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_26386cca-a582-46e8-aba9-04cb9624a7a3" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_2c21e0f2-7d93-49d4-b462-9eeab2679d7a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_0e13875a-ed04-4caa-ace3-da3832b97919" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_26386cca-a582-46e8-aba9-04cb9624a7a3" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_0e13875a-ed04-4caa-ace3-da3832b97919" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_a8f12182-61f9-4235-a2c8-c9b69bc56b6c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_26386cca-a582-46e8-aba9-04cb9624a7a3" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_a8f12182-61f9-4235-a2c8-c9b69bc56b6c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_1cb41bf0-a8a6-428d-b258-d9359dcf74ab" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_06164ddd-3565-41d6-8801-b2e628c4821f" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_1cb41bf0-a8a6-428d-b258-d9359dcf74ab" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_1cb41bf0-a8a6-428d-b258-d9359dcf74ab_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_1cb41bf0-a8a6-428d-b258-d9359dcf74ab" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_1cb41bf0-a8a6-428d-b258-d9359dcf74ab_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_662875b9-5b78-4c74-a7d5-5ddc67ed0ce1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_1cb41bf0-a8a6-428d-b258-d9359dcf74ab" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_662875b9-5b78-4c74-a7d5-5ddc67ed0ce1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_95ebb705-1927-4fd3-a255-5bf47ddc6021" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementsRecurringMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_662875b9-5b78-4c74-a7d5-5ddc67ed0ce1" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_95ebb705-1927-4fd3-a255-5bf47ddc6021" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAxis_11460f46-81f6-49d9-9f75-9888c1afdd95" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashAndCashEquivalentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_06164ddd-3565-41d6-8801-b2e628c4821f" xlink:to="loc_us-gaap_CashAndCashEquivalentsAxis_11460f46-81f6-49d9-9f75-9888c1afdd95" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_11460f46-81f6-49d9-9f75-9888c1afdd95_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_11460f46-81f6-49d9-9f75-9888c1afdd95" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_11460f46-81f6-49d9-9f75-9888c1afdd95_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_433bfd44-e28f-4850-9fc0-4f197b9c1681" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_11460f46-81f6-49d9-9f75-9888c1afdd95" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_433bfd44-e28f-4850-9fc0-4f197b9c1681" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_b3eb38fc-1638-4db6-988e-465c1ef7c537" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_433bfd44-e28f-4850-9fc0-4f197b9c1681" xlink:to="loc_us-gaap_MoneyMarketFundsMember_b3eb38fc-1638-4db6-988e-465c1ef7c537" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_dd108143-e78e-489d-9798-a3d7debea90f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommercialPaperMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_433bfd44-e28f-4850-9fc0-4f197b9c1681" xlink:to="loc_us-gaap_CommercialPaperMember_dd108143-e78e-489d-9798-a3d7debea90f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_63b19611-07af-48f6-bf3a-da0d9ca0042d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_06164ddd-3565-41d6-8801-b2e628c4821f" xlink:to="loc_us-gaap_FinancialInstrumentAxis_63b19611-07af-48f6-bf3a-da0d9ca0042d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_63b19611-07af-48f6-bf3a-da0d9ca0042d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_63b19611-07af-48f6-bf3a-da0d9ca0042d" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_63b19611-07af-48f6-bf3a-da0d9ca0042d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_5b9be742-aa8c-49fc-be60-913853eb687e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_63b19611-07af-48f6-bf3a-da0d9ca0042d" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_5b9be742-aa8c-49fc-be60-913853eb687e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentDebtSecuritiesMember_f1a958f0-5e1e-479f-ab6f-75f585c02c69" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_USGovernmentDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_5b9be742-aa8c-49fc-be60-913853eb687e" xlink:to="loc_us-gaap_USGovernmentDebtSecuritiesMember_f1a958f0-5e1e-479f-ab6f-75f585c02c69" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignGovernmentDebtSecuritiesMember_26424d84-814b-48ee-820c-755488515fff" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ForeignGovernmentDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_5b9be742-aa8c-49fc-be60-913853eb687e" xlink:to="loc_us-gaap_ForeignGovernmentDebtSecuritiesMember_26424d84-814b-48ee-820c-755488515fff" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_f3b1c633-0ba0-4844-9bf2-4cc9f9df57ab" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CorporateDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_5b9be742-aa8c-49fc-be60-913853eb687e" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_f3b1c633-0ba0-4844-9bf2-4cc9f9df57ab" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_e5a5074a-dc89-4ba3-8430-50cf143ee7b8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommercialPaperMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_5b9be742-aa8c-49fc-be60-913853eb687e" xlink:to="loc_us-gaap_CommercialPaperMember_e5a5074a-dc89-4ba3-8430-50cf143ee7b8" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_1bab7091-9a6c-4d68-adaa-5865cc8a4a75" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_02429e57-13e8-4685-8af3-bbae98c9c947" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_1bab7091-9a6c-4d68-adaa-5865cc8a4a75" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsFairValueDisclosure_54d6a89a-2f5d-4c24-a1f1-1b654ff4e9f7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InvestmentsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_02429e57-13e8-4685-8af3-bbae98c9c947" xlink:to="loc_us-gaap_InvestmentsFairValueDisclosure_54d6a89a-2f5d-4c24-a1f1-1b654ff4e9f7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_LongTermInvestmentsFairValueDisclosure_13e750ee-d289-4e7f-be5b-54e08ff64702" xlink:href="swtx-20231231.xsd#swtx_LongTermInvestmentsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_02429e57-13e8-4685-8af3-bbae98c9c947" xlink:to="loc_swtx_LongTermInvestmentsFairValueDisclosure_13e750ee-d289-4e7f-be5b-54e08ff64702" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_b3ed0e4b-6d7e-4e91-af4b-4d3d3fa61371" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_02429e57-13e8-4685-8af3-bbae98c9c947" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_b3ed0e4b-6d7e-4e91-af4b-4d3d3fa61371" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.springworkstx.com/role/PropertyandEquipmentnetScheduleofPropertyandEquipmentDetails" xlink:type="simple" xlink:href="swtx-20231231.xsd#PropertyandEquipmentnetScheduleofPropertyandEquipmentDetails"/>
  <link:definitionLink xlink:role="http://www.springworkstx.com/role/PropertyandEquipmentnetScheduleofPropertyandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_70c96a6c-364b-4f38-bc05-faeede1e0451" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_4eb136e3-108e-4919-a2a2-a302adb9d2d6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_70c96a6c-364b-4f38-bc05-faeede1e0451" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_4eb136e3-108e-4919-a2a2-a302adb9d2d6" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_35ee9979-bd39-4dbf-84f4-f36f1412fb9a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_4eb136e3-108e-4919-a2a2-a302adb9d2d6" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_35ee9979-bd39-4dbf-84f4-f36f1412fb9a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_35ee9979-bd39-4dbf-84f4-f36f1412fb9a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_35ee9979-bd39-4dbf-84f4-f36f1412fb9a" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_35ee9979-bd39-4dbf-84f4-f36f1412fb9a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_9ab2290b-0cf4-496d-ae2b-065e721f63d7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_35ee9979-bd39-4dbf-84f4-f36f1412fb9a" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_9ab2290b-0cf4-496d-ae2b-065e721f63d7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_74b2b73e-5112-4c1a-9779-0c600d179626" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LeaseholdImprovementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_9ab2290b-0cf4-496d-ae2b-065e721f63d7" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_74b2b73e-5112-4c1a-9779-0c600d179626" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComputerEquipmentMember_6c8f8b80-87b2-4106-965e-3044604cc6a7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ComputerEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_9ab2290b-0cf4-496d-ae2b-065e721f63d7" xlink:to="loc_us-gaap_ComputerEquipmentMember_6c8f8b80-87b2-4106-965e-3044604cc6a7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquipmentMember_dc11305e-5557-408b-90f1-7ca27c830af8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_9ab2290b-0cf4-496d-ae2b-065e721f63d7" xlink:to="loc_us-gaap_EquipmentMember_dc11305e-5557-408b-90f1-7ca27c830af8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_756d28ca-dbc0-4d53-8816-00c8b6dc1455" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FurnitureAndFixturesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_9ab2290b-0cf4-496d-ae2b-065e721f63d7" xlink:to="loc_us-gaap_FurnitureAndFixturesMember_756d28ca-dbc0-4d53-8816-00c8b6dc1455" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_eedb2a5f-e3fc-45f1-b5f9-b105cdef3dfe" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SoftwareAndSoftwareDevelopmentCostsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_9ab2290b-0cf4-496d-ae2b-065e721f63d7" xlink:to="loc_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_eedb2a5f-e3fc-45f1-b5f9-b105cdef3dfe" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionInProgressMember_19c3a740-d3b6-48e2-a020-f86fa635bc5c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConstructionInProgressMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_9ab2290b-0cf4-496d-ae2b-065e721f63d7" xlink:to="loc_us-gaap_ConstructionInProgressMember_19c3a740-d3b6-48e2-a020-f86fa635bc5c" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_06e3d4fc-cc87-40c3-9c90-2fb6635aef19" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_4eb136e3-108e-4919-a2a2-a302adb9d2d6" xlink:to="loc_srt_RangeAxis_06e3d4fc-cc87-40c3-9c90-2fb6635aef19" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_06e3d4fc-cc87-40c3-9c90-2fb6635aef19_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_06e3d4fc-cc87-40c3-9c90-2fb6635aef19" xlink:to="loc_srt_RangeMember_06e3d4fc-cc87-40c3-9c90-2fb6635aef19_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_baaa24c7-7c94-4cec-af79-fd346527ca1e" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_06e3d4fc-cc87-40c3-9c90-2fb6635aef19" xlink:to="loc_srt_RangeMember_baaa24c7-7c94-4cec-af79-fd346527ca1e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_5a274eeb-3718-45d3-8ed0-69d6d763d3c6" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_baaa24c7-7c94-4cec-af79-fd346527ca1e" xlink:to="loc_srt_MinimumMember_5a274eeb-3718-45d3-8ed0-69d6d763d3c6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_2fe75926-793a-4e09-bc68-d790b642a277" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_baaa24c7-7c94-4cec-af79-fd346527ca1e" xlink:to="loc_srt_MaximumMember_2fe75926-793a-4e09-bc68-d790b642a277" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_0c450830-73da-4bb9-afc4-4eda754832ad" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_70c96a6c-364b-4f38-bc05-faeede1e0451" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_0c450830-73da-4bb9-afc4-4eda754832ad" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_18e7b75c-d7c1-4efa-bbd7-9668f85d374a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_70c96a6c-364b-4f38-bc05-faeede1e0451" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_18e7b75c-d7c1-4efa-bbd7-9668f85d374a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_d9d3a1e8-64ff-4c9b-909f-ad37b344e74a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_70c96a6c-364b-4f38-bc05-faeede1e0451" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_d9d3a1e8-64ff-4c9b-909f-ad37b344e74a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_2dc936a5-3ffa-4242-b2c7-549099a2854e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_70c96a6c-364b-4f38-bc05-faeede1e0451" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_2dc936a5-3ffa-4242-b2c7-549099a2854e" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.springworkstx.com/role/IntangibleAssetsnetScheduleofFiniteLivedIntangibleAssetsDetails" xlink:type="simple" xlink:href="swtx-20231231.xsd#IntangibleAssetsnetScheduleofFiniteLivedIntangibleAssetsDetails"/>
  <link:definitionLink xlink:role="http://www.springworkstx.com/role/IntangibleAssetsnetScheduleofFiniteLivedIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f9ffa09c-d804-478b-a514-84cbd6db5df4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_bad2b3e9-f3bb-4e40-8ab6-0385778484fc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f9ffa09c-d804-478b-a514-84cbd6db5df4" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_bad2b3e9-f3bb-4e40-8ab6-0385778484fc" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_e3156304-a35c-470b-8a6d-f465516476e6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_bad2b3e9-f3bb-4e40-8ab6-0385778484fc" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_e3156304-a35c-470b-8a6d-f465516476e6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_e3156304-a35c-470b-8a6d-f465516476e6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_e3156304-a35c-470b-8a6d-f465516476e6" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_e3156304-a35c-470b-8a6d-f465516476e6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_2d3e29b0-7cf9-4293-ae86-bad06faca14b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_e3156304-a35c-470b-8a6d-f465516476e6" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_2d3e29b0-7cf9-4293-ae86-bad06faca14b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LicensingAgreementsMember_8fe6f7fd-e88f-4c1a-89a8-4d57359f1181" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LicensingAgreementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_2d3e29b0-7cf9-4293-ae86-bad06faca14b" xlink:to="loc_us-gaap_LicensingAgreementsMember_8fe6f7fd-e88f-4c1a-89a8-4d57359f1181" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_e8ff32d9-f869-4e1d-8f5f-7e33af9cc349" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsNetAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f9ffa09c-d804-478b-a514-84cbd6db5df4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_e8ff32d9-f869-4e1d-8f5f-7e33af9cc349" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_6dbf9e6c-451a-4978-81f8-a006cae57b6e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_e8ff32d9-f869-4e1d-8f5f-7e33af9cc349" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_6dbf9e6c-451a-4978-81f8-a006cae57b6e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_22d40bac-df3f-4cba-8c5e-ac97ed763029" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_e8ff32d9-f869-4e1d-8f5f-7e33af9cc349" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_22d40bac-df3f-4cba-8c5e-ac97ed763029" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_4fb241a8-d387-4ba5-bc53-137385230133" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_e8ff32d9-f869-4e1d-8f5f-7e33af9cc349" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_4fb241a8-d387-4ba5-bc53-137385230133" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.springworkstx.com/role/IntangibleAssetsnetNarrativeDetails" xlink:type="simple" xlink:href="swtx-20231231.xsd#IntangibleAssetsnetNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.springworkstx.com/role/IntangibleAssetsnetNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_2b4a3a2f-693c-4787-be78-57ed6390b13b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_8d7b06c7-40e1-42f2-a2f0-14c1e363a54d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_2b4a3a2f-693c-4787-be78-57ed6390b13b" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_8d7b06c7-40e1-42f2-a2f0-14c1e363a54d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_8b854cb0-309e-4fc3-929a-9fd3827fd00b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_8d7b06c7-40e1-42f2-a2f0-14c1e363a54d" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_8b854cb0-309e-4fc3-929a-9fd3827fd00b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_8b854cb0-309e-4fc3-929a-9fd3827fd00b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_8b854cb0-309e-4fc3-929a-9fd3827fd00b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_8b854cb0-309e-4fc3-929a-9fd3827fd00b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_b6ee9fb4-caae-487c-8be1-3c43fc505842" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_8b854cb0-309e-4fc3-929a-9fd3827fd00b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_b6ee9fb4-caae-487c-8be1-3c43fc505842" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PatentsMember_ad655465-d994-496e-889f-694633a29651" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PatentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_b6ee9fb4-caae-487c-8be1-3c43fc505842" xlink:to="loc_us-gaap_PatentsMember_ad655465-d994-496e-889f-694633a29651" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_227880c9-bc0b-49ce-b87a-7aafc90f55a0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_2b4a3a2f-693c-4787-be78-57ed6390b13b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_227880c9-bc0b-49ce-b87a-7aafc90f55a0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_0b9968ba-ac8b-4535-b775-e91d282af8dd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_2b4a3a2f-693c-4787-be78-57ed6390b13b" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_0b9968ba-ac8b-4535-b775-e91d282af8dd" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.springworkstx.com/role/LeasesNarrativeDetails" xlink:type="simple" xlink:href="swtx-20231231.xsd#LeasesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.springworkstx.com/role/LeasesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionLineItems_778c03ff-a729-4213-8bc6-a22e17bcb14a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeLeaseDescriptionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionTable_f39ff76b-2f99-4493-8bc1-a87aadcbd23b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeLeaseDescriptionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_778c03ff-a729-4213-8bc6-a22e17bcb14a" xlink:to="loc_us-gaap_LesseeLeaseDescriptionTable_f39ff76b-2f99-4493-8bc1-a87aadcbd23b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis_1bf38d61-5f94-48c9-9a5b-33215f5f6372" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_f39ff76b-2f99-4493-8bc1-a87aadcbd23b" xlink:to="loc_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis_1bf38d61-5f94-48c9-9a5b-33215f5f6372" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_1bf38d61-5f94-48c9-9a5b-33215f5f6372_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis_1bf38d61-5f94-48c9-9a5b-33215f5f6372" xlink:to="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_1bf38d61-5f94-48c9-9a5b-33215f5f6372_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_456cb68c-d770-484d-bddc-d2a1e5610df8" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis_1bf38d61-5f94-48c9-9a5b-33215f5f6372" xlink:to="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_456cb68c-d770-484d-bddc-d2a1e5610df8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_OperatingLeaseInDurhamNCMember_6e91ccb2-fba8-4d6b-adf2-bd09d3a8244f" xlink:href="swtx-20231231.xsd#swtx_OperatingLeaseInDurhamNCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_456cb68c-d770-484d-bddc-d2a1e5610df8" xlink:to="loc_swtx_OperatingLeaseInDurhamNCMember_6e91ccb2-fba8-4d6b-adf2-bd09d3a8244f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_CorporateHeadquartersStamfordConnecticutMember_e473ac49-57cf-40e1-9f9c-33d58a9993d3" xlink:href="swtx-20231231.xsd#swtx_CorporateHeadquartersStamfordConnecticutMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_456cb68c-d770-484d-bddc-d2a1e5610df8" xlink:to="loc_swtx_CorporateHeadquartersStamfordConnecticutMember_e473ac49-57cf-40e1-9f9c-33d58a9993d3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_ResearchTriangleParkMember_792f078b-4c39-42fa-a13c-3f32a2a9546c" xlink:href="swtx-20231231.xsd#swtx_ResearchTriangleParkMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_456cb68c-d770-484d-bddc-d2a1e5610df8" xlink:to="loc_swtx_ResearchTriangleParkMember_792f078b-4c39-42fa-a13c-3f32a2a9546c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_LesseeOperatingLeaseRenewalTermAxis_b1ae819d-a39e-4b29-a21f-91ea715a2005" xlink:href="swtx-20231231.xsd#swtx_LesseeOperatingLeaseRenewalTermAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_f39ff76b-2f99-4493-8bc1-a87aadcbd23b" xlink:to="loc_swtx_LesseeOperatingLeaseRenewalTermAxis_b1ae819d-a39e-4b29-a21f-91ea715a2005" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_LesseeOperatingLeaseRenewalTermDomain_b1ae819d-a39e-4b29-a21f-91ea715a2005_default" xlink:href="swtx-20231231.xsd#swtx_LesseeOperatingLeaseRenewalTermDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_swtx_LesseeOperatingLeaseRenewalTermAxis_b1ae819d-a39e-4b29-a21f-91ea715a2005" xlink:to="loc_swtx_LesseeOperatingLeaseRenewalTermDomain_b1ae819d-a39e-4b29-a21f-91ea715a2005_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_LesseeOperatingLeaseRenewalTermDomain_580c69ce-69b9-4cc9-bba5-f44f8211fa83" xlink:href="swtx-20231231.xsd#swtx_LesseeOperatingLeaseRenewalTermDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_swtx_LesseeOperatingLeaseRenewalTermAxis_b1ae819d-a39e-4b29-a21f-91ea715a2005" xlink:to="loc_swtx_LesseeOperatingLeaseRenewalTermDomain_580c69ce-69b9-4cc9-bba5-f44f8211fa83" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_LesseeOperatingLeaseRenewalOptionOneMember_58ee5644-e679-473d-9546-15f6037cfdcc" xlink:href="swtx-20231231.xsd#swtx_LesseeOperatingLeaseRenewalOptionOneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_swtx_LesseeOperatingLeaseRenewalTermDomain_580c69ce-69b9-4cc9-bba5-f44f8211fa83" xlink:to="loc_swtx_LesseeOperatingLeaseRenewalOptionOneMember_58ee5644-e679-473d-9546-15f6037cfdcc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_LesseeOperatingLeaseRenewalOptionTwoMember_97ec4a3e-1fc3-466d-bef8-aa33d06942a8" xlink:href="swtx-20231231.xsd#swtx_LesseeOperatingLeaseRenewalOptionTwoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_swtx_LesseeOperatingLeaseRenewalTermDomain_580c69ce-69b9-4cc9-bba5-f44f8211fa83" xlink:to="loc_swtx_LesseeOperatingLeaseRenewalOptionTwoMember_97ec4a3e-1fc3-466d-bef8-aa33d06942a8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_e87a3741-e43a-416c-b609-47964d516f91" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_f39ff76b-2f99-4493-8bc1-a87aadcbd23b" xlink:to="loc_srt_RangeAxis_e87a3741-e43a-416c-b609-47964d516f91" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_e87a3741-e43a-416c-b609-47964d516f91_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_e87a3741-e43a-416c-b609-47964d516f91" xlink:to="loc_srt_RangeMember_e87a3741-e43a-416c-b609-47964d516f91_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_bd794f24-9375-4c0f-aa9f-403db2a39332" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_e87a3741-e43a-416c-b609-47964d516f91" xlink:to="loc_srt_RangeMember_bd794f24-9375-4c0f-aa9f-403db2a39332" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_d7b229c4-9b4e-4554-a4ae-7fc04ae740b1" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_bd794f24-9375-4c0f-aa9f-403db2a39332" xlink:to="loc_srt_MinimumMember_d7b229c4-9b4e-4554-a4ae-7fc04ae740b1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_89b10f41-392d-44ef-ac7f-7ea334db4b9a" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_bd794f24-9375-4c0f-aa9f-403db2a39332" xlink:to="loc_srt_MaximumMember_89b10f41-392d-44ef-ac7f-7ea334db4b9a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseTermOfContract_871d6af2-4d6c-445e-89ab-d829d7e45dd0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseTermOfContract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_778c03ff-a729-4213-8bc6-a22e17bcb14a" xlink:to="loc_us-gaap_LesseeOperatingLeaseTermOfContract_871d6af2-4d6c-445e-89ab-d829d7e45dd0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_LesseeOperatingLeaseNumberOfRenewalOptions_e3a6a07b-6e71-4e33-8c7c-c3e5292b5e06" xlink:href="swtx-20231231.xsd#swtx_LesseeOperatingLeaseNumberOfRenewalOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_778c03ff-a729-4213-8bc6-a22e17bcb14a" xlink:to="loc_swtx_LesseeOperatingLeaseNumberOfRenewalOptions_e3a6a07b-6e71-4e33-8c7c-c3e5292b5e06" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_862ec057-19e4-4001-9514-4e181d627aff" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseRenewalTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_778c03ff-a729-4213-8bc6-a22e17bcb14a" xlink:to="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_862ec057-19e4-4001-9514-4e181d627aff" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_AnnualIncreaseInLeasePaymentsPercentage_7603c190-cb17-4b30-a9a4-6e007acaeb04" xlink:href="swtx-20231231.xsd#swtx_AnnualIncreaseInLeasePaymentsPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_778c03ff-a729-4213-8bc6-a22e17bcb14a" xlink:to="loc_swtx_AnnualIncreaseInLeasePaymentsPercentage_7603c190-cb17-4b30-a9a4-6e007acaeb04" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_NumberOfYearsTheLeasePaymentsWillIncrease_4c0262a7-beef-4fdb-910c-beb8db6328d2" xlink:href="swtx-20231231.xsd#swtx_NumberOfYearsTheLeasePaymentsWillIncrease"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_778c03ff-a729-4213-8bc6-a22e17bcb14a" xlink:to="loc_swtx_NumberOfYearsTheLeasePaymentsWillIncrease_4c0262a7-beef-4fdb-910c-beb8db6328d2" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.springworkstx.com/role/EquityBasedCompensationEquitybasedcompensationexpenserelatedtorestrictedstockandstockoptionsDetails" xlink:type="simple" xlink:href="swtx-20231231.xsd#EquityBasedCompensationEquitybasedcompensationexpenserelatedtorestrictedstockandstockoptionsDetails"/>
  <link:definitionLink xlink:role="http://www.springworkstx.com/role/EquityBasedCompensationEquitybasedcompensationexpenserelatedtorestrictedstockandstockoptionsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_e4a332d8-682d-405c-a2dd-7f8dc9d39bf5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_9609258b-93a6-451b-8554-7ca58f359b30" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_e4a332d8-682d-405c-a2dd-7f8dc9d39bf5" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_9609258b-93a6-451b-8554-7ca58f359b30" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_668bf418-b9eb-4131-b5e5-de3cc736e564" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_9609258b-93a6-451b-8554-7ca58f359b30" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_668bf418-b9eb-4131-b5e5-de3cc736e564" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_668bf418-b9eb-4131-b5e5-de3cc736e564_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_668bf418-b9eb-4131-b5e5-de3cc736e564" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_668bf418-b9eb-4131-b5e5-de3cc736e564_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_34a85cbb-212a-4e3c-aa64-785c82ec7039" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_668bf418-b9eb-4131-b5e5-de3cc736e564" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_34a85cbb-212a-4e3c-aa64-785c82ec7039" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_42bc3a7a-9b6a-4675-8452-708cdd6d94c9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_34a85cbb-212a-4e3c-aa64-785c82ec7039" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_42bc3a7a-9b6a-4675-8452-708cdd6d94c9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_fb0a4cf1-944b-4d89-bd5f-a9aa36410a3c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_34a85cbb-212a-4e3c-aa64-785c82ec7039" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_fb0a4cf1-944b-4d89-bd5f-a9aa36410a3c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_58e814f1-8cdc-4a7c-b5be-89f412dc5502" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_e4a332d8-682d-405c-a2dd-7f8dc9d39bf5" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_58e814f1-8cdc-4a7c-b5be-89f412dc5502" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.springworkstx.com/role/EquityBasedCompensation2019EquityIncentivePlanDetails" xlink:type="simple" xlink:href="swtx-20231231.xsd#EquityBasedCompensation2019EquityIncentivePlanDetails"/>
  <link:definitionLink xlink:role="http://www.springworkstx.com/role/EquityBasedCompensation2019EquityIncentivePlanDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_541903e7-80c6-49e4-a2d9-f74837849a67" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_85bf2ddd-f55a-4086-a65a-2defc73f90ae" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_541903e7-80c6-49e4-a2d9-f74837849a67" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_85bf2ddd-f55a-4086-a65a-2defc73f90ae" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_77710e68-3d8e-445e-bf2b-f52b0c08efa8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_85bf2ddd-f55a-4086-a65a-2defc73f90ae" xlink:to="loc_us-gaap_PlanNameAxis_77710e68-3d8e-445e-bf2b-f52b0c08efa8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_77710e68-3d8e-445e-bf2b-f52b0c08efa8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_77710e68-3d8e-445e-bf2b-f52b0c08efa8" xlink:to="loc_us-gaap_PlanNameDomain_77710e68-3d8e-445e-bf2b-f52b0c08efa8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_c6edcff8-9948-4c09-9605-b9356ec380a5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_77710e68-3d8e-445e-bf2b-f52b0c08efa8" xlink:to="loc_us-gaap_PlanNameDomain_c6edcff8-9948-4c09-9605-b9356ec380a5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_EquityIncentivePlan2019Member_6884cb3d-63e9-4c85-a02d-f396f5ef05eb" xlink:href="swtx-20231231.xsd#swtx_EquityIncentivePlan2019Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_c6edcff8-9948-4c09-9605-b9356ec380a5" xlink:to="loc_swtx_EquityIncentivePlan2019Member_6884cb3d-63e9-4c85-a02d-f396f5ef05eb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GranteeStatusAxis_476ddab7-00f0-4bec-b53a-6d8b6a0d0c32" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GranteeStatusAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_85bf2ddd-f55a-4086-a65a-2defc73f90ae" xlink:to="loc_us-gaap_GranteeStatusAxis_476ddab7-00f0-4bec-b53a-6d8b6a0d0c32" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GranteeStatusDomain_476ddab7-00f0-4bec-b53a-6d8b6a0d0c32_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GranteeStatusDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_GranteeStatusAxis_476ddab7-00f0-4bec-b53a-6d8b6a0d0c32" xlink:to="loc_us-gaap_GranteeStatusDomain_476ddab7-00f0-4bec-b53a-6d8b6a0d0c32_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GranteeStatusDomain_a82c6a1d-a4b6-498d-abd6-0cb3eeb1594a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GranteeStatusDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_GranteeStatusAxis_476ddab7-00f0-4bec-b53a-6d8b6a0d0c32" xlink:to="loc_us-gaap_GranteeStatusDomain_a82c6a1d-a4b6-498d-abd6-0cb3eeb1594a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedPaymentArrangementEmployeeMember_0030c1c4-6c16-44ee-b861-a4ca16b42232" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedPaymentArrangementEmployeeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GranteeStatusDomain_a82c6a1d-a4b6-498d-abd6-0cb3eeb1594a" xlink:to="loc_us-gaap_ShareBasedPaymentArrangementEmployeeMember_0030c1c4-6c16-44ee-b861-a4ca16b42232" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedPaymentArrangementNonemployeeMember_0ac9deee-54e2-42d0-b3bf-26db99cb9146" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedPaymentArrangementNonemployeeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GranteeStatusDomain_a82c6a1d-a4b6-498d-abd6-0cb3eeb1594a" xlink:to="loc_us-gaap_ShareBasedPaymentArrangementNonemployeeMember_0ac9deee-54e2-42d0-b3bf-26db99cb9146" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_150165d8-9d52-4ada-b759-e519afed8e63" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_85bf2ddd-f55a-4086-a65a-2defc73f90ae" xlink:to="loc_srt_RangeAxis_150165d8-9d52-4ada-b759-e519afed8e63" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_150165d8-9d52-4ada-b759-e519afed8e63_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_150165d8-9d52-4ada-b759-e519afed8e63" xlink:to="loc_srt_RangeMember_150165d8-9d52-4ada-b759-e519afed8e63_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_57f910dc-80b6-4ae5-ac9c-04ddf936749c" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_150165d8-9d52-4ada-b759-e519afed8e63" xlink:to="loc_srt_RangeMember_57f910dc-80b6-4ae5-ac9c-04ddf936749c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_42809c5a-761f-4edb-8619-90ec35eb9aa2" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_57f910dc-80b6-4ae5-ac9c-04ddf936749c" xlink:to="loc_srt_MinimumMember_42809c5a-761f-4edb-8619-90ec35eb9aa2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_e9d0fa0f-4a7c-40cb-9dfd-d9e850d7e34a" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_57f910dc-80b6-4ae5-ac9c-04ddf936749c" xlink:to="loc_srt_MaximumMember_e9d0fa0f-4a7c-40cb-9dfd-d9e850d7e34a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfAnnualIncreaseInOutstandingStock_d9e4e678-d14d-48cd-a953-c6f1dfa71149" xlink:href="swtx-20231231.xsd#swtx_ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfAnnualIncreaseInOutstandingStock"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_541903e7-80c6-49e4-a2d9-f74837849a67" xlink:to="loc_swtx_ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfAnnualIncreaseInOutstandingStock_d9e4e678-d14d-48cd-a953-c6f1dfa71149" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_ad921f49-a7bd-4d89-b5e7-e94ca1db35f1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_541903e7-80c6-49e4-a2d9-f74837849a67" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_ad921f49-a7bd-4d89-b5e7-e94ca1db35f1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_57c49b49-962f-4863-8548-b01960b3d61f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_541903e7-80c6-49e4-a2d9-f74837849a67" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_57c49b49-962f-4863-8548-b01960b3d61f" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.springworkstx.com/role/EquityBasedCompensation2019EmployeeStockPurchasePlanDetails" xlink:type="simple" xlink:href="swtx-20231231.xsd#EquityBasedCompensation2019EmployeeStockPurchasePlanDetails"/>
  <link:definitionLink xlink:role="http://www.springworkstx.com/role/EquityBasedCompensation2019EmployeeStockPurchasePlanDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4b418f6e-4603-461e-be50-ae2099146a23" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_a0cfd812-53c4-4e51-9d2a-5af876047df9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4b418f6e-4603-461e-be50-ae2099146a23" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_a0cfd812-53c4-4e51-9d2a-5af876047df9" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_55c79450-be4f-4424-a542-56eaffc8314c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_a0cfd812-53c4-4e51-9d2a-5af876047df9" xlink:to="loc_us-gaap_PlanNameAxis_55c79450-be4f-4424-a542-56eaffc8314c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_55c79450-be4f-4424-a542-56eaffc8314c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_55c79450-be4f-4424-a542-56eaffc8314c" xlink:to="loc_us-gaap_PlanNameDomain_55c79450-be4f-4424-a542-56eaffc8314c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_e9903eae-0267-4ced-ac11-af7f7427a465" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_55c79450-be4f-4424-a542-56eaffc8314c" xlink:to="loc_us-gaap_PlanNameDomain_e9903eae-0267-4ced-ac11-af7f7427a465" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_EmployeeStockPurchasePlan2019Member_f052dd68-524b-4bf1-8393-28282c64792f" xlink:href="swtx-20231231.xsd#swtx_EmployeeStockPurchasePlan2019Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_e9903eae-0267-4ced-ac11-af7f7427a465" xlink:to="loc_swtx_EmployeeStockPurchasePlan2019Member_f052dd68-524b-4bf1-8393-28282c64792f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_CeoPerformanceAwardMember_979e5106-5c28-4d03-b035-9d369a0ccfc3" xlink:href="swtx-20231231.xsd#swtx_CeoPerformanceAwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_e9903eae-0267-4ced-ac11-af7f7427a465" xlink:to="loc_swtx_CeoPerformanceAwardMember_979e5106-5c28-4d03-b035-9d369a0ccfc3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_3c338d37-22d0-4b75-aa60-735d368f1e98" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_a0cfd812-53c4-4e51-9d2a-5af876047df9" xlink:to="loc_us-gaap_AwardTypeAxis_3c338d37-22d0-4b75-aa60-735d368f1e98" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_3c338d37-22d0-4b75-aa60-735d368f1e98_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_3c338d37-22d0-4b75-aa60-735d368f1e98" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_3c338d37-22d0-4b75-aa60-735d368f1e98_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_0bf58282-d827-48ba-919f-a11eecc796bd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_3c338d37-22d0-4b75-aa60-735d368f1e98" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_0bf58282-d827-48ba-919f-a11eecc796bd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_25f6d99e-90c7-4fd3-a80c-f8797adf55fd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_0bf58282-d827-48ba-919f-a11eecc796bd" xlink:to="loc_us-gaap_EmployeeStockOptionMember_25f6d99e-90c7-4fd3-a80c-f8797adf55fd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_c4fda2cd-9237-49c2-bd55-4bbd6fecb4d8" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_a0cfd812-53c4-4e51-9d2a-5af876047df9" xlink:to="loc_srt_RangeAxis_c4fda2cd-9237-49c2-bd55-4bbd6fecb4d8" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_c4fda2cd-9237-49c2-bd55-4bbd6fecb4d8_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_c4fda2cd-9237-49c2-bd55-4bbd6fecb4d8" xlink:to="loc_srt_RangeMember_c4fda2cd-9237-49c2-bd55-4bbd6fecb4d8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_01a633f8-e815-4b57-9350-491a22226c4c" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_c4fda2cd-9237-49c2-bd55-4bbd6fecb4d8" xlink:to="loc_srt_RangeMember_01a633f8-e815-4b57-9350-491a22226c4c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_dfdfd82a-6a15-4ffb-ad26-70300b7d4e7c" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_01a633f8-e815-4b57-9350-491a22226c4c" xlink:to="loc_srt_MinimumMember_dfdfd82a-6a15-4ffb-ad26-70300b7d4e7c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_233e21a5-935b-4039-a9b3-cdf5795c970e" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_01a633f8-e815-4b57-9350-491a22226c4c" xlink:to="loc_srt_MaximumMember_233e21a5-935b-4039-a9b3-cdf5795c970e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_a2241814-818c-4089-8a6c-05996a7e6e1a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockCapitalSharesReservedForFutureIssuance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4b418f6e-4603-461e-be50-ae2099146a23" xlink:to="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_a2241814-818c-4089-8a6c-05996a7e6e1a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_ShareBasedCompensationArrangementByShareBasedPaymentAwardAutomaticIncreaseToSharesAuthorizedByNumberOfShares_21895b49-4ba4-4ca4-add5-6e32fd444e56" xlink:href="swtx-20231231.xsd#swtx_ShareBasedCompensationArrangementByShareBasedPaymentAwardAutomaticIncreaseToSharesAuthorizedByNumberOfShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4b418f6e-4603-461e-be50-ae2099146a23" xlink:to="loc_swtx_ShareBasedCompensationArrangementByShareBasedPaymentAwardAutomaticIncreaseToSharesAuthorizedByNumberOfShares_21895b49-4ba4-4ca4-add5-6e32fd444e56" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_ShareBasedCompensationArrangementByShareBasedPaymentAwardAutomaticIncreaseToSharesAuthorizedAsPercentageOfOutstandingStock_d0f6e020-3968-4908-900a-b756c96bae3c" xlink:href="swtx-20231231.xsd#swtx_ShareBasedCompensationArrangementByShareBasedPaymentAwardAutomaticIncreaseToSharesAuthorizedAsPercentageOfOutstandingStock"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4b418f6e-4603-461e-be50-ae2099146a23" xlink:to="loc_swtx_ShareBasedCompensationArrangementByShareBasedPaymentAwardAutomaticIncreaseToSharesAuthorizedAsPercentageOfOutstandingStock_d0f6e020-3968-4908-900a-b756c96bae3c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_46298630-5d11-49f3-a5dc-0f6376209554" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4b418f6e-4603-461e-be50-ae2099146a23" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_46298630-5d11-49f3-a5dc-0f6376209554" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum_d6c9384e-2ef1-4d0b-98bc-152488b78150" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4b418f6e-4603-461e-be50-ae2099146a23" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum_d6c9384e-2ef1-4d0b-98bc-152488b78150" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum_fdf35996-0a86-4d0b-8468-0c1c00c01758" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4b418f6e-4603-461e-be50-ae2099146a23" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum_fdf35996-0a86-4d0b-8468-0c1c00c01758" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_6f561ee0-4be3-4a7e-abdc-7a0e8a6c6d3c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4b418f6e-4603-461e-be50-ae2099146a23" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_6f561ee0-4be3-4a7e-abdc-7a0e8a6c6d3c" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_b5cbf16a-0617-4b0a-b6b6-6f12427fa33f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4b418f6e-4603-461e-be50-ae2099146a23" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_b5cbf16a-0617-4b0a-b6b6-6f12427fa33f" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_22ddc025-5266-4c64-9bbb-311aadff64cf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4b418f6e-4603-461e-be50-ae2099146a23" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_22ddc025-5266-4c64-9bbb-311aadff64cf" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_28dd00ad-a203-43d3-a449-b05f79467652" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4b418f6e-4603-461e-be50-ae2099146a23" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_28dd00ad-a203-43d3-a449-b05f79467652" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_a1789298-b270-48c2-8185-3e3aa01157fe" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4b418f6e-4603-461e-be50-ae2099146a23" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_a1789298-b270-48c2-8185-3e3aa01157fe" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_1fb57147-4c9b-439c-88da-9b53bf348544" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4b418f6e-4603-461e-be50-ae2099146a23" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_1fb57147-4c9b-439c-88da-9b53bf348544" xlink:type="arc" order="11"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.springworkstx.com/role/EquityBasedCompensationRestrictedstockDetails" xlink:type="simple" xlink:href="swtx-20231231.xsd#EquityBasedCompensationRestrictedstockDetails"/>
  <link:definitionLink xlink:role="http://www.springworkstx.com/role/EquityBasedCompensationRestrictedstockDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_8009ea54-7c73-4159-a60e-46183a8c5bf3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_fc35c80f-6f5e-4ca9-ab54-64c7901e9cab" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_8009ea54-7c73-4159-a60e-46183a8c5bf3" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_fc35c80f-6f5e-4ca9-ab54-64c7901e9cab" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_98522132-7cc8-4146-9e68-45fadeb7eed0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_fc35c80f-6f5e-4ca9-ab54-64c7901e9cab" xlink:to="loc_us-gaap_AwardTypeAxis_98522132-7cc8-4146-9e68-45fadeb7eed0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_98522132-7cc8-4146-9e68-45fadeb7eed0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_98522132-7cc8-4146-9e68-45fadeb7eed0" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_98522132-7cc8-4146-9e68-45fadeb7eed0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_5df4bbbf-af73-43a1-a0d8-54fe5ea6bf8c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_98522132-7cc8-4146-9e68-45fadeb7eed0" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_5df4bbbf-af73-43a1-a0d8-54fe5ea6bf8c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockMember_7daf3f86-737f-4e9a-9271-77ad3845983e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_5df4bbbf-af73-43a1-a0d8-54fe5ea6bf8c" xlink:to="loc_us-gaap_RestrictedStockMember_7daf3f86-737f-4e9a-9271-77ad3845983e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_af9d03f1-73d4-4de9-b78e-24f61eab7bec" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_5df4bbbf-af73-43a1-a0d8-54fe5ea6bf8c" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_af9d03f1-73d4-4de9-b78e-24f61eab7bec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_bbae850e-57f2-4007-bb40-e54966cadd2d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_8009ea54-7c73-4159-a60e-46183a8c5bf3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_bbae850e-57f2-4007-bb40-e54966cadd2d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_46e8168b-1e86-4e83-99e1-20d27c55f326" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_bbae850e-57f2-4007-bb40-e54966cadd2d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_46e8168b-1e86-4e83-99e1-20d27c55f326" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_6ad4d4c2-5f4b-45a2-a676-30c0561c87c5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_bbae850e-57f2-4007-bb40-e54966cadd2d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_6ad4d4c2-5f4b-45a2-a676-30c0561c87c5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_a99b63fc-1f9e-4d24-a2a6-a9d6876eabf5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_bbae850e-57f2-4007-bb40-e54966cadd2d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_a99b63fc-1f9e-4d24-a2a6-a9d6876eabf5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_22703b5f-774e-4e1a-a05f-36e5014dd290" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_bbae850e-57f2-4007-bb40-e54966cadd2d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_22703b5f-774e-4e1a-a05f-36e5014dd290" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_32d84316-430e-4b39-86b6-777828b63cd7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_3ac62493-8bed-4eec-8dcc-3eb54a317c22" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_8009ea54-7c73-4159-a60e-46183a8c5bf3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_3ac62493-8bed-4eec-8dcc-3eb54a317c22" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_6c267bdf-fd93-47ca-9b59-0befca266e38" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_3ac62493-8bed-4eec-8dcc-3eb54a317c22" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_6c267bdf-fd93-47ca-9b59-0befca266e38" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_4f13e4c5-756d-4be0-b766-d96ba1851744" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_3ac62493-8bed-4eec-8dcc-3eb54a317c22" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_4f13e4c5-756d-4be0-b766-d96ba1851744" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_8c54648e-2306-4643-af0c-2f138a066e2e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_3ac62493-8bed-4eec-8dcc-3eb54a317c22" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_8c54648e-2306-4643-af0c-2f138a066e2e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_055becef-0fa1-49ef-a396-f83baeb462ef" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_3ac62493-8bed-4eec-8dcc-3eb54a317c22" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_055becef-0fa1-49ef-a396-f83baeb462ef" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_c15fb4d6-2e8b-4026-9056-ca9135323068" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_23037ac4-3ab2-404f-bf09-da8655d01660" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_8009ea54-7c73-4159-a60e-46183a8c5bf3" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_23037ac4-3ab2-404f-bf09-da8655d01660" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_40eb66ad-a675-4af0-9206-549aa6ca0536" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_8009ea54-7c73-4159-a60e-46183a8c5bf3" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_40eb66ad-a675-4af0-9206-549aa6ca0536" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_4c7fe1b7-5921-4a0e-9a00-b39eefcd3808" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_8009ea54-7c73-4159-a60e-46183a8c5bf3" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_4c7fe1b7-5921-4a0e-9a00-b39eefcd3808" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.springworkstx.com/role/EquityBasedCompensationPerformanceStockUnitsDetails" xlink:type="simple" xlink:href="swtx-20231231.xsd#EquityBasedCompensationPerformanceStockUnitsDetails"/>
  <link:definitionLink xlink:role="http://www.springworkstx.com/role/EquityBasedCompensationPerformanceStockUnitsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_add848bb-6564-4947-9554-cb2467260e62" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_482bdffc-1d4e-4703-ad98-726007b1b339" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_add848bb-6564-4947-9554-cb2467260e62" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_482bdffc-1d4e-4703-ad98-726007b1b339" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualAxis_8483face-b3a1-42a7-a5a2-dc596bf45433" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_TitleOfIndividualAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_482bdffc-1d4e-4703-ad98-726007b1b339" xlink:to="loc_srt_TitleOfIndividualAxis_8483face-b3a1-42a7-a5a2-dc596bf45433" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_8483face-b3a1-42a7-a5a2-dc596bf45433_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_TitleOfIndividualWithRelationshipToEntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_TitleOfIndividualAxis_8483face-b3a1-42a7-a5a2-dc596bf45433" xlink:to="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_8483face-b3a1-42a7-a5a2-dc596bf45433_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_69355da1-0a6b-418b-a67a-63fd77ec849a" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_TitleOfIndividualWithRelationshipToEntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_TitleOfIndividualAxis_8483face-b3a1-42a7-a5a2-dc596bf45433" xlink:to="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_69355da1-0a6b-418b-a67a-63fd77ec849a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ChiefExecutiveOfficerMember_202121c2-597b-4d3b-a145-afd2a43f5cae" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ChiefExecutiveOfficerMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_69355da1-0a6b-418b-a67a-63fd77ec849a" xlink:to="loc_srt_ChiefExecutiveOfficerMember_202121c2-597b-4d3b-a145-afd2a43f5cae" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_b66b1b35-fa14-47f4-97ad-b7ac879b76ee" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_482bdffc-1d4e-4703-ad98-726007b1b339" xlink:to="loc_us-gaap_AwardTypeAxis_b66b1b35-fa14-47f4-97ad-b7ac879b76ee" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_b66b1b35-fa14-47f4-97ad-b7ac879b76ee_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_b66b1b35-fa14-47f4-97ad-b7ac879b76ee" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_b66b1b35-fa14-47f4-97ad-b7ac879b76ee_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_58b65816-3bc6-4012-9e58-76cacefc7eba" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_b66b1b35-fa14-47f4-97ad-b7ac879b76ee" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_58b65816-3bc6-4012-9e58-76cacefc7eba" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_PerformanceStockUnitsMember_6e51660f-49f0-45ce-984f-17bc87832eac" xlink:href="swtx-20231231.xsd#swtx_PerformanceStockUnitsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_58b65816-3bc6-4012-9e58-76cacefc7eba" xlink:to="loc_swtx_PerformanceStockUnitsMember_6e51660f-49f0-45ce-984f-17bc87832eac" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_eb86887d-309f-45c0-8c5e-a721e5c472a0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_add848bb-6564-4947-9554-cb2467260e62" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_eb86887d-309f-45c0-8c5e-a721e5c472a0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfSharesSubjectToModification_cdbdb2e7-c626-45bf-843a-be28bc7a19de" xlink:href="swtx-20231231.xsd#swtx_ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfSharesSubjectToModification"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_add848bb-6564-4947-9554-cb2467260e62" xlink:to="loc_swtx_ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfSharesSubjectToModification_cdbdb2e7-c626-45bf-843a-be28bc7a19de" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_25ea748f-b677-4d2c-ac1a-825a27f2aaa2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_add848bb-6564-4947-9554-cb2467260e62" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_25ea748f-b677-4d2c-ac1a-825a27f2aaa2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_c131751e-3d3b-46ba-88ed-bb9107506f40" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_add848bb-6564-4947-9554-cb2467260e62" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_c131751e-3d3b-46ba-88ed-bb9107506f40" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_18ac154e-d76b-4488-8600-919728c7b258" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_add848bb-6564-4947-9554-cb2467260e62" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_18ac154e-d76b-4488-8600-919728c7b258" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.springworkstx.com/role/LicenseandCollaborationAgreementsDetails" xlink:type="simple" xlink:href="swtx-20231231.xsd#LicenseandCollaborationAgreementsDetails"/>
  <link:definitionLink xlink:role="http://www.springworkstx.com/role/LicenseandCollaborationAgreementsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_dcfa95b3-3bb8-4ea3-9dcc-dd9d77e741b8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_868422b5-4863-41fc-a24d-6805130cd48b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_dcfa95b3-3bb8-4ea3-9dcc-dd9d77e741b8" xlink:to="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_868422b5-4863-41fc-a24d-6805130cd48b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_01aaea67-5c7d-4a73-a949-6c60990c82c9" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_868422b5-4863-41fc-a24d-6805130cd48b" xlink:to="loc_srt_CounterpartyNameAxis_01aaea67-5c7d-4a73-a949-6c60990c82c9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01aaea67-5c7d-4a73-a949-6c60990c82c9_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_01aaea67-5c7d-4a73-a949-6c60990c82c9" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_01aaea67-5c7d-4a73-a949-6c60990c82c9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_21aa6183-2ebe-4e85-81ea-0b9d6264cb1a" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_01aaea67-5c7d-4a73-a949-6c60990c82c9" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_21aa6183-2ebe-4e85-81ea-0b9d6264cb1a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_PfizerMember_47590e6f-1ce8-47e4-b80b-0b42daee99ce" xlink:href="swtx-20231231.xsd#swtx_PfizerMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_21aa6183-2ebe-4e85-81ea-0b9d6264cb1a" xlink:to="loc_swtx_PfizerMember_47590e6f-1ce8-47e4-b80b-0b42daee99ce" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_BeigeneLtdMember_f79f6bfa-e402-49d3-bf02-42d68d3c4e61" xlink:href="swtx-20231231.xsd#swtx_BeigeneLtdMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_21aa6183-2ebe-4e85-81ea-0b9d6264cb1a" xlink:to="loc_swtx_BeigeneLtdMember_f79f6bfa-e402-49d3-bf02-42d68d3c4e61" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_GSKMember_32ea8ed0-a74b-4eaa-afcd-ca8bff0fa33d" xlink:href="swtx-20231231.xsd#swtx_GSKMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_21aa6183-2ebe-4e85-81ea-0b9d6264cb1a" xlink:to="loc_swtx_GSKMember_32ea8ed0-a74b-4eaa-afcd-ca8bff0fa33d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_JazzPharmaceuticalsIrelandLimitedMember_35dcb072-3296-448d-a79c-caf050efff05" xlink:href="swtx-20231231.xsd#swtx_JazzPharmaceuticalsIrelandLimitedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_21aa6183-2ebe-4e85-81ea-0b9d6264cb1a" xlink:to="loc_swtx_JazzPharmaceuticalsIrelandLimitedMember_35dcb072-3296-448d-a79c-caf050efff05" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_f976e2c1-649f-4214-bb12-6556cc813f0d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_868422b5-4863-41fc-a24d-6805130cd48b" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_f976e2c1-649f-4214-bb12-6556cc813f0d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_f976e2c1-649f-4214-bb12-6556cc813f0d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_f976e2c1-649f-4214-bb12-6556cc813f0d" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_f976e2c1-649f-4214-bb12-6556cc813f0d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_0c8f2f7e-fde0-4d38-8bfd-d71e234fe443" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_f976e2c1-649f-4214-bb12-6556cc813f0d" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_0c8f2f7e-fde0-4d38-8bfd-d71e234fe443" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LicenseAgreementTermsMember_94784526-553d-410e-a176-5da6e5256eda" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LicenseAgreementTermsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_0c8f2f7e-fde0-4d38-8bfd-d71e234fe443" xlink:to="loc_us-gaap_LicenseAgreementTermsMember_94784526-553d-410e-a176-5da6e5256eda" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_ClinicalCollaborationAgreementMember_d19443ca-9ca1-47f1-8e01-e0293da8480a" xlink:href="swtx-20231231.xsd#swtx_ClinicalCollaborationAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_0c8f2f7e-fde0-4d38-8bfd-d71e234fe443" xlink:to="loc_swtx_ClinicalCollaborationAgreementMember_d19443ca-9ca1-47f1-8e01-e0293da8480a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_c941990b-0d3e-40e6-85a3-677c76bef581" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_868422b5-4863-41fc-a24d-6805130cd48b" xlink:to="loc_us-gaap_TypeOfArrangementAxis_c941990b-0d3e-40e6-85a3-677c76bef581" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_c941990b-0d3e-40e6-85a3-677c76bef581_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_c941990b-0d3e-40e6-85a3-677c76bef581" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_c941990b-0d3e-40e6-85a3-677c76bef581_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_b8d18374-77cc-4001-a15c-77a4fd4167cd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_c941990b-0d3e-40e6-85a3-677c76bef581" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_b8d18374-77cc-4001-a15c-77a4fd4167cd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_AssetPurchaseAndExclusiveLicenseAgreementMember_917a3ccc-c624-4ce5-a471-1a40c53277ee" xlink:href="swtx-20231231.xsd#swtx_AssetPurchaseAndExclusiveLicenseAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_b8d18374-77cc-4001-a15c-77a4fd4167cd" xlink:to="loc_swtx_AssetPurchaseAndExclusiveLicenseAgreementMember_917a3ccc-c624-4ce5-a471-1a40c53277ee" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_AssetPurchaseAndExclusiveLicenseAgreementDevelopmentMilestonesMember_743d3ec7-c414-48d0-9db0-9bdfaa9777cb" xlink:href="swtx-20231231.xsd#swtx_AssetPurchaseAndExclusiveLicenseAgreementDevelopmentMilestonesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_b8d18374-77cc-4001-a15c-77a4fd4167cd" xlink:to="loc_swtx_AssetPurchaseAndExclusiveLicenseAgreementDevelopmentMilestonesMember_743d3ec7-c414-48d0-9db0-9bdfaa9777cb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_AssetPurchaseAndExclusiveLicenseAgreementCommercialMilestonesMember_a8ae0da1-d524-47ac-91b0-8a741e89de3d" xlink:href="swtx-20231231.xsd#swtx_AssetPurchaseAndExclusiveLicenseAgreementCommercialMilestonesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_b8d18374-77cc-4001-a15c-77a4fd4167cd" xlink:to="loc_swtx_AssetPurchaseAndExclusiveLicenseAgreementCommercialMilestonesMember_a8ae0da1-d524-47ac-91b0-8a741e89de3d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_818a244e-20f7-4a02-b64e-92e3a58491cb" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_868422b5-4863-41fc-a24d-6805130cd48b" xlink:to="loc_srt_ProductOrServiceAxis_818a244e-20f7-4a02-b64e-92e3a58491cb" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_818a244e-20f7-4a02-b64e-92e3a58491cb_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_818a244e-20f7-4a02-b64e-92e3a58491cb" xlink:to="loc_srt_ProductsAndServicesDomain_818a244e-20f7-4a02-b64e-92e3a58491cb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_700f2fc6-f1f6-4dac-b5fe-5756b899a2bd" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_818a244e-20f7-4a02-b64e-92e3a58491cb" xlink:to="loc_srt_ProductsAndServicesDomain_700f2fc6-f1f6-4dac-b5fe-5756b899a2bd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_NirogacestatMember_7e82c64f-bfab-4319-b815-cef294921aa0" xlink:href="swtx-20231231.xsd#swtx_NirogacestatMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_700f2fc6-f1f6-4dac-b5fe-5756b899a2bd" xlink:to="loc_swtx_NirogacestatMember_7e82c64f-bfab-4319-b815-cef294921aa0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_MirdametinibMember_c5d25be7-d502-4f26-90f7-3df71733e78f" xlink:href="swtx-20231231.xsd#swtx_MirdametinibMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_700f2fc6-f1f6-4dac-b5fe-5756b899a2bd" xlink:to="loc_swtx_MirdametinibMember_c5d25be7-d502-4f26-90f7-3df71733e78f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_OGSIVEOMember_3ebe3641-0181-408e-89a8-6b5a87da83d7" xlink:href="swtx-20231231.xsd#swtx_OGSIVEOMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_700f2fc6-f1f6-4dac-b5fe-5756b899a2bd" xlink:to="loc_swtx_OGSIVEOMember_3ebe3641-0181-408e-89a8-6b5a87da83d7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_ee1ae80d-6262-4f32-bb39-4a0dbf53d21b" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_868422b5-4863-41fc-a24d-6805130cd48b" xlink:to="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_ee1ae80d-6262-4f32-bb39-4a0dbf53d21b" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_ee1ae80d-6262-4f32-bb39-4a0dbf53d21b_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_ee1ae80d-6262-4f32-bb39-4a0dbf53d21b" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_ee1ae80d-6262-4f32-bb39-4a0dbf53d21b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_5c615f88-5f60-4c21-acd8-e8b4618fd594" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_ee1ae80d-6262-4f32-bb39-4a0dbf53d21b" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_5c615f88-5f60-4c21-acd8-e8b4618fd594" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_KatholiekeUniversiteitLeuvenMember_5ad42ce5-1e03-401e-8389-6fad51777cb4" xlink:href="swtx-20231231.xsd#swtx_KatholiekeUniversiteitLeuvenMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_5c615f88-5f60-4c21-acd8-e8b4618fd594" xlink:to="loc_swtx_KatholiekeUniversiteitLeuvenMember_5ad42ce5-1e03-401e-8389-6fad51777cb4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_DanaFarberCancerInstituteMember_e962d6f5-32da-4267-a6f8-a2e120a35cdc" xlink:href="swtx-20231231.xsd#swtx_DanaFarberCancerInstituteMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_5c615f88-5f60-4c21-acd8-e8b4618fd594" xlink:to="loc_swtx_DanaFarberCancerInstituteMember_e962d6f5-32da-4267-a6f8-a2e120a35cdc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_34273db3-4aca-48a7-b5df-6260d1ed0426" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_868422b5-4863-41fc-a24d-6805130cd48b" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_34273db3-4aca-48a7-b5df-6260d1ed0426" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_34273db3-4aca-48a7-b5df-6260d1ed0426_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_34273db3-4aca-48a7-b5df-6260d1ed0426" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_34273db3-4aca-48a7-b5df-6260d1ed0426_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_f24ae40b-189f-49a0-9526-10b4137545e5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_34273db3-4aca-48a7-b5df-6260d1ed0426" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_f24ae40b-189f-49a0-9526-10b4137545e5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrivatePlacementMember_29e79703-ccb0-442c-973b-7e6cca1868c1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PrivatePlacementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_f24ae40b-189f-49a0-9526-10b4137545e5" xlink:to="loc_us-gaap_PrivatePlacementMember_29e79703-ccb0-442c-973b-7e6cca1868c1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_cae44df6-734b-41bc-9a0c-50676eb6ead8" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_868422b5-4863-41fc-a24d-6805130cd48b" xlink:to="loc_srt_RangeAxis_cae44df6-734b-41bc-9a0c-50676eb6ead8" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_cae44df6-734b-41bc-9a0c-50676eb6ead8_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_cae44df6-734b-41bc-9a0c-50676eb6ead8" xlink:to="loc_srt_RangeMember_cae44df6-734b-41bc-9a0c-50676eb6ead8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_9d514065-74fb-423a-a7c2-9d4f081f9222" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_cae44df6-734b-41bc-9a0c-50676eb6ead8" xlink:to="loc_srt_RangeMember_9d514065-74fb-423a-a7c2-9d4f081f9222" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_92c3dd29-7ee0-41d5-bbc4-3aabb3d46d0f" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_9d514065-74fb-423a-a7c2-9d4f081f9222" xlink:to="loc_srt_MaximumMember_92c3dd29-7ee0-41d5-bbc4-3aabb3d46d0f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_MilestonePaymentsOutstanding_ea31ffc2-d294-404c-aadb-f00b3d936a88" xlink:href="swtx-20231231.xsd#swtx_MilestonePaymentsOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_dcfa95b3-3bb8-4ea3-9dcc-dd9d77e741b8" xlink:to="loc_swtx_MilestonePaymentsOutstanding_ea31ffc2-d294-404c-aadb-f00b3d936a88" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_MinimumPeriodAfterFirstCommercialSaleOnCountryByCountryBasis_f5f6c998-be18-457f-ba51-1cab53a60ca4" xlink:href="swtx-20231231.xsd#swtx_MinimumPeriodAfterFirstCommercialSaleOnCountryByCountryBasis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_dcfa95b3-3bb8-4ea3-9dcc-dd9d77e741b8" xlink:to="loc_swtx_MinimumPeriodAfterFirstCommercialSaleOnCountryByCountryBasis_f5f6c998-be18-457f-ba51-1cab53a60ca4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_9fd06e4b-f83c-4a42-a7c7-fe09784c2716" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_dcfa95b3-3bb8-4ea3-9dcc-dd9d77e741b8" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_9fd06e4b-f83c-4a42-a7c7-fe09784c2716" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_NonRefundableUpfrontFees_14b2ba5c-f3fc-4f85-ba5a-70dcef8028c2" xlink:href="swtx-20231231.xsd#swtx_NonRefundableUpfrontFees"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_dcfa95b3-3bb8-4ea3-9dcc-dd9d77e741b8" xlink:to="loc_swtx_NonRefundableUpfrontFees_14b2ba5c-f3fc-4f85-ba5a-70dcef8028c2" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_PotentialFuturePaymentsUponAchievementOfCertainClinicalDevelopmentReceivable_32c61c6a-a007-4058-a9ae-f1cd409f2f61" xlink:href="swtx-20231231.xsd#swtx_PotentialFuturePaymentsUponAchievementOfCertainClinicalDevelopmentReceivable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_dcfa95b3-3bb8-4ea3-9dcc-dd9d77e741b8" xlink:to="loc_swtx_PotentialFuturePaymentsUponAchievementOfCertainClinicalDevelopmentReceivable_32c61c6a-a007-4058-a9ae-f1cd409f2f61" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_4514c6f1-0557-448d-8397-e9fe3116e470" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_dcfa95b3-3bb8-4ea3-9dcc-dd9d77e741b8" xlink:to="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_4514c6f1-0557-448d-8397-e9fe3116e470" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_SaleOfStockConsiderationReceivedOnTransactionGrossProceeds_75b76486-e3e1-4870-b47e-ef7a52b8f9cf" xlink:href="swtx-20231231.xsd#swtx_SaleOfStockConsiderationReceivedOnTransactionGrossProceeds"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_dcfa95b3-3bb8-4ea3-9dcc-dd9d77e741b8" xlink:to="loc_swtx_SaleOfStockConsiderationReceivedOnTransactionGrossProceeds_75b76486-e3e1-4870-b47e-ef7a52b8f9cf" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_e858276d-310e-4a67-9bbc-e322475f9190" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SaleOfStockPricePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_dcfa95b3-3bb8-4ea3-9dcc-dd9d77e741b8" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_e858276d-310e-4a67-9bbc-e322475f9190" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_SaleOfStockPricePremiumRate_163d725c-da5e-422d-9147-3e510d117b26" xlink:href="swtx-20231231.xsd#swtx_SaleOfStockPricePremiumRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_dcfa95b3-3bb8-4ea3-9dcc-dd9d77e741b8" xlink:to="loc_swtx_SaleOfStockPricePremiumRate_163d725c-da5e-422d-9147-3e510d117b26" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_SalesOfStockPremiumTerm_7dd51419-35f1-4988-a658-b4f8ab6a023b" xlink:href="swtx-20231231.xsd#swtx_SalesOfStockPremiumTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_dcfa95b3-3bb8-4ea3-9dcc-dd9d77e741b8" xlink:to="loc_swtx_SalesOfStockPremiumTerm_7dd51419-35f1-4988-a658-b4f8ab6a023b" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_fa298041-2a65-4c7c-9423-077a674dc1d1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_dcfa95b3-3bb8-4ea3-9dcc-dd9d77e741b8" xlink:to="loc_us-gaap_CommonStockValue_fa298041-2a65-4c7c-9423-077a674dc1d1" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilities_6a2cf6f1-5022-4db3-925e-3e4813b3b8fb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_dcfa95b3-3bb8-4ea3-9dcc-dd9d77e741b8" xlink:to="loc_us-gaap_OtherLiabilities_6a2cf6f1-5022-4db3-925e-3e4813b3b8fb" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_CollaborativeArrangementMaximumProceedsFromAchievementOfCommercialMilestone_d1e48ff3-0aa5-44a7-8218-66ed31c5b745" xlink:href="swtx-20231231.xsd#swtx_CollaborativeArrangementMaximumProceedsFromAchievementOfCommercialMilestone"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_dcfa95b3-3bb8-4ea3-9dcc-dd9d77e741b8" xlink:to="loc_swtx_CollaborativeArrangementMaximumProceedsFromAchievementOfCommercialMilestone_d1e48ff3-0aa5-44a7-8218-66ed31c5b745" xlink:type="arc" order="12"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.springworkstx.com/role/EquityMethodInvestmentDetails" xlink:type="simple" xlink:href="swtx-20231231.xsd#EquityMethodInvestmentDetails"/>
  <link:definitionLink xlink:role="http://www.springworkstx.com/role/EquityMethodInvestmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_39151085-4a9c-442d-b189-08fe4d884fdc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_215f9f78-dfe8-467e-ba8d-40db4c4956a7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_39151085-4a9c-442d-b189-08fe4d884fdc" xlink:to="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_215f9f78-dfe8-467e-ba8d-40db4c4956a7" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_3b18c54d-f24c-4efe-8b76-9595b732a63b" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_215f9f78-dfe8-467e-ba8d-40db4c4956a7" xlink:to="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_3b18c54d-f24c-4efe-8b76-9595b732a63b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_3b18c54d-f24c-4efe-8b76-9595b732a63b_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_3b18c54d-f24c-4efe-8b76-9595b732a63b" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_3b18c54d-f24c-4efe-8b76-9595b732a63b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_0166cd3c-0f8f-4fc4-bcfb-ff6078362934" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_3b18c54d-f24c-4efe-8b76-9595b732a63b" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_0166cd3c-0f8f-4fc4-bcfb-ff6078362934" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_MapkureMember_d77c9536-4aac-4054-8353-1353b557a579" xlink:href="swtx-20231231.xsd#swtx_MapkureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_0166cd3c-0f8f-4fc4-bcfb-ff6078362934" xlink:to="loc_swtx_MapkureMember_d77c9536-4aac-4054-8353-1353b557a579" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_53e6b4ab-34e0-4420-a172-330c80f32ae2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_215f9f78-dfe8-467e-ba8d-40db4c4956a7" xlink:to="loc_us-gaap_StatementClassOfStockAxis_53e6b4ab-34e0-4420-a172-330c80f32ae2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_53e6b4ab-34e0-4420-a172-330c80f32ae2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_53e6b4ab-34e0-4420-a172-330c80f32ae2" xlink:to="loc_us-gaap_ClassOfStockDomain_53e6b4ab-34e0-4420-a172-330c80f32ae2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_16b9c8ca-0a29-4df9-9752-fa72318a28e0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_53e6b4ab-34e0-4420-a172-330c80f32ae2" xlink:to="loc_us-gaap_ClassOfStockDomain_16b9c8ca-0a29-4df9-9752-fa72318a28e0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_bdeda09d-6367-4f2e-a77a-bb0179065d85" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SeriesAPreferredStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_16b9c8ca-0a29-4df9-9752-fa72318a28e0" xlink:to="loc_us-gaap_SeriesAPreferredStockMember_bdeda09d-6367-4f2e-a77a-bb0179065d85" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesBPreferredStockMember_892a68e3-d881-4b89-976e-77c568a7cb44" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SeriesBPreferredStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_16b9c8ca-0a29-4df9-9752-fa72318a28e0" xlink:to="loc_us-gaap_SeriesBPreferredStockMember_892a68e3-d881-4b89-976e-77c568a7cb44" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesCPreferredStockMember_7e14feca-9b01-4b12-b142-79ec0ce9ede1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SeriesCPreferredStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_16b9c8ca-0a29-4df9-9752-fa72318a28e0" xlink:to="loc_us-gaap_SeriesCPreferredStockMember_7e14feca-9b01-4b12-b142-79ec0ce9ede1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_ad7277b3-8038-4a54-9443-132677287c85" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_215f9f78-dfe8-467e-ba8d-40db4c4956a7" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_ad7277b3-8038-4a54-9443-132677287c85" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_ad7277b3-8038-4a54-9443-132677287c85_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_ad7277b3-8038-4a54-9443-132677287c85" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_ad7277b3-8038-4a54-9443-132677287c85_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_80f8af5f-d652-4232-ba3e-3c3a76e28c28" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_ad7277b3-8038-4a54-9443-132677287c85" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_80f8af5f-d652-4232-ba3e-3c3a76e28c28" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_ace035a9-5bad-4435-8917-c3e24b838dc1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_80f8af5f-d652-4232-ba3e-3c3a76e28c28" xlink:to="loc_us-gaap_SubsequentEventMember_ace035a9-5bad-4435-8917-c3e24b838dc1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementScenarioAxis_62a12f06-9053-4d19-8236-d8404b129dc3" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_StatementScenarioAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_215f9f78-dfe8-467e-ba8d-40db4c4956a7" xlink:to="loc_srt_StatementScenarioAxis_62a12f06-9053-4d19-8236-d8404b129dc3" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_62a12f06-9053-4d19-8236-d8404b129dc3_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementScenarioAxis_62a12f06-9053-4d19-8236-d8404b129dc3" xlink:to="loc_srt_ScenarioUnspecifiedDomain_62a12f06-9053-4d19-8236-d8404b129dc3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_37413fda-c3c0-4058-b1a4-e6eb72e01ff2" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementScenarioAxis_62a12f06-9053-4d19-8236-d8404b129dc3" xlink:to="loc_srt_ScenarioUnspecifiedDomain_37413fda-c3c0-4058-b1a4-e6eb72e01ff2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScenarioPlanMember_249d8ab8-f9d7-47a0-a377-f31487529693" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScenarioPlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ScenarioUnspecifiedDomain_37413fda-c3c0-4058-b1a4-e6eb72e01ff2" xlink:to="loc_us-gaap_ScenarioPlanMember_249d8ab8-f9d7-47a0-a377-f31487529693" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_EquityMethodInvestmentSharesAcquired_3a7e4a3f-e040-424f-80e4-39f097439489" xlink:href="swtx-20231231.xsd#swtx_EquityMethodInvestmentSharesAcquired"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_39151085-4a9c-442d-b189-08fe4d884fdc" xlink:to="loc_swtx_EquityMethodInvestmentSharesAcquired_3a7e4a3f-e040-424f-80e4-39f097439489" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_9f794a3f-ab65-44b6-a59a-a38b3366c164" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_39151085-4a9c-442d-b189-08fe4d884fdc" xlink:to="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_9f794a3f-ab65-44b6-a59a-a38b3366c164" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestments_98faead1-02ad-430c-9e89-fbd0c650e730" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityMethodInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_39151085-4a9c-442d-b189-08fe4d884fdc" xlink:to="loc_us-gaap_EquityMethodInvestments_98faead1-02ad-430c-9e89-fbd0c650e730" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireEquityMethodInvestments_a35a3293-3d2d-4fd4-ab1b-4af0caf99281" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquireEquityMethodInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_39151085-4a9c-442d-b189-08fe4d884fdc" xlink:to="loc_us-gaap_PaymentsToAcquireEquityMethodInvestments_a35a3293-3d2d-4fd4-ab1b-4af0caf99281" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_6af229e0-bf92-41e2-b888-d463ba694383" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromEquityMethodInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_39151085-4a9c-442d-b189-08fe4d884fdc" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_6af229e0-bf92-41e2-b888-d463ba694383" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.springworkstx.com/role/IncomeTaxesNarrativeDetails" xlink:type="simple" xlink:href="swtx-20231231.xsd#IncomeTaxesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.springworkstx.com/role/IncomeTaxesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_swtx_DisclosureOfIncomeTaxesLineItems_a5527779-0bed-4e1c-8656-2aa718debabc" xlink:href="swtx-20231231.xsd#swtx_DisclosureOfIncomeTaxesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_DisclosureOfIncomeTaxesTable_89e25fdf-2c56-4510-b89e-f6ab340b1b3a" xlink:href="swtx-20231231.xsd#swtx_DisclosureOfIncomeTaxesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_swtx_DisclosureOfIncomeTaxesLineItems_a5527779-0bed-4e1c-8656-2aa718debabc" xlink:to="loc_swtx_DisclosureOfIncomeTaxesTable_89e25fdf-2c56-4510-b89e-f6ab340b1b3a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis_8238d649-0263-43e8-9b87-f1986a1f4b05" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxAuthorityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_swtx_DisclosureOfIncomeTaxesTable_89e25fdf-2c56-4510-b89e-f6ab340b1b3a" xlink:to="loc_us-gaap_IncomeTaxAuthorityAxis_8238d649-0263-43e8-9b87-f1986a1f4b05" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_8238d649-0263-43e8-9b87-f1986a1f4b05_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_8238d649-0263-43e8-9b87-f1986a1f4b05" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_8238d649-0263-43e8-9b87-f1986a1f4b05_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_ef25fc9c-664e-47c3-b579-e43a98b880db" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_8238d649-0263-43e8-9b87-f1986a1f4b05" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_ef25fc9c-664e-47c3-b579-e43a98b880db" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StateAndLocalJurisdictionMember_e5d1002c-75f4-4dfe-b9cc-de949cb97b9a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StateAndLocalJurisdictionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_ef25fc9c-664e-47c3-b579-e43a98b880db" xlink:to="loc_us-gaap_StateAndLocalJurisdictionMember_e5d1002c-75f4-4dfe-b9cc-de949cb97b9a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_CityMember_dc8f2133-b769-4dfa-81f2-5979c814df8e" xlink:href="swtx-20231231.xsd#swtx_CityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_ef25fc9c-664e-47c3-b579-e43a98b880db" xlink:to="loc_swtx_CityMember_dc8f2133-b769-4dfa-81f2-5979c814df8e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsDomestic_4f0eb7ca-832d-42f6-8afd-fdee52729269" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsDomestic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_swtx_DisclosureOfIncomeTaxesLineItems_a5527779-0bed-4e1c-8656-2aa718debabc" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsDomestic_4f0eb7ca-832d-42f6-8afd-fdee52729269" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsStateAndLocal_6635b99b-d0f8-4962-ba8d-9d0204f433fe" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsStateAndLocal"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_swtx_DisclosureOfIncomeTaxesLineItems_a5527779-0bed-4e1c-8656-2aa718debabc" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsStateAndLocal_6635b99b-d0f8-4962-ba8d-9d0204f433fe" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwards_7313e2c1-4dc5-49d8-8468-dd07cdf16d57" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLossCarryforwards"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_swtx_DisclosureOfIncomeTaxesLineItems_a5527779-0bed-4e1c-8656-2aa718debabc" xlink:to="loc_us-gaap_OperatingLossCarryforwards_7313e2c1-4dc5-49d8-8468-dd07cdf16d57" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_PercentageOfTaxableIncomeAvailableToOffset_b187d907-1f8b-4695-9a66-8ffd75020ede" xlink:href="swtx-20231231.xsd#swtx_PercentageOfTaxableIncomeAvailableToOffset"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_swtx_DisclosureOfIncomeTaxesLineItems_a5527779-0bed-4e1c-8656-2aa718debabc" xlink:to="loc_swtx_PercentageOfTaxableIncomeAvailableToOffset_b187d907-1f8b-4695-9a66-8ffd75020ede" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsSubjectToExpiration_15b4ceee-fbc8-4b4e-aa3f-8873622dbc7e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsSubjectToExpiration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_swtx_DisclosureOfIncomeTaxesLineItems_a5527779-0bed-4e1c-8656-2aa718debabc" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsSubjectToExpiration_15b4ceee-fbc8-4b4e-aa3f-8873622dbc7e" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardAmount_4c10237b-4d91-4c1c-bcdf-1fb65a4f9647" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TaxCreditCarryforwardAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_swtx_DisclosureOfIncomeTaxesLineItems_a5527779-0bed-4e1c-8656-2aa718debabc" xlink:to="loc_us-gaap_TaxCreditCarryforwardAmount_4c10237b-4d91-4c1c-bcdf-1fb65a4f9647" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestAccrued_1ba7fd39-56d2-40bf-a9b7-bc77b7ab9172" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestAccrued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_swtx_DisclosureOfIncomeTaxesLineItems_a5527779-0bed-4e1c-8656-2aa718debabc" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestAccrued_1ba7fd39-56d2-40bf-a9b7-bc77b7ab9172" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_42d020f4-61fb-4cca-89fd-140703fb0e76" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_swtx_DisclosureOfIncomeTaxesLineItems_a5527779-0bed-4e1c-8656-2aa718debabc" xlink:to="loc_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_42d020f4-61fb-4cca-89fd-140703fb0e76" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_4dc1920d-67ad-4240-9b2d-c0f22bfac682" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_swtx_DisclosureOfIncomeTaxesLineItems_a5527779-0bed-4e1c-8656-2aa718debabc" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_4dc1920d-67ad-4240-9b2d-c0f22bfac682" xlink:type="arc" order="8"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.springworkstx.com/role/NetLossperSharePotentialcommonunitsnotincludedinthecalculationofthedilutednetlossperunitandshareDetails" xlink:type="simple" xlink:href="swtx-20231231.xsd#NetLossperSharePotentialcommonunitsnotincludedinthecalculationofthedilutednetlossperunitandshareDetails"/>
  <link:definitionLink xlink:role="http://www.springworkstx.com/role/NetLossperSharePotentialcommonunitsnotincludedinthecalculationofthedilutednetlossperunitandshareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_c927a380-0e94-4ace-a4f6-b1b95c6a7d32" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_4e9244cb-3380-49dd-a873-69e832c5b602" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_c927a380-0e94-4ace-a4f6-b1b95c6a7d32" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_4e9244cb-3380-49dd-a873-69e832c5b602" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_ca420cca-edca-442f-9ee1-a4f0c857122d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_4e9244cb-3380-49dd-a873-69e832c5b602" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_ca420cca-edca-442f-9ee1-a4f0c857122d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_ca420cca-edca-442f-9ee1-a4f0c857122d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_ca420cca-edca-442f-9ee1-a4f0c857122d" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_ca420cca-edca-442f-9ee1-a4f0c857122d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_83d4e2fe-0b95-4b95-8856-262434f47b77" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_ca420cca-edca-442f-9ee1-a4f0c857122d" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_83d4e2fe-0b95-4b95-8856-262434f47b77" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_94c44e58-2e5a-4c8a-a37e-a7c71f8232c0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_83d4e2fe-0b95-4b95-8856-262434f47b77" xlink:to="loc_us-gaap_CommonStockMember_94c44e58-2e5a-4c8a-a37e-a7c71f8232c0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_a7b81633-8f99-4e50-8b0b-bc9a93886490" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_83d4e2fe-0b95-4b95-8856-262434f47b77" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_a7b81633-8f99-4e50-8b0b-bc9a93886490" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_PerformanceStockUnitsMember_c21611c4-9402-4cbb-a19b-b4ed854da986" xlink:href="swtx-20231231.xsd#swtx_PerformanceStockUnitsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_83d4e2fe-0b95-4b95-8856-262434f47b77" xlink:to="loc_swtx_PerformanceStockUnitsMember_c21611c4-9402-4cbb-a19b-b4ed854da986" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockMember_20779fcb-7544-471e-91e6-ebb4f44bc701" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_83d4e2fe-0b95-4b95-8856-262434f47b77" xlink:to="loc_us-gaap_RestrictedStockMember_20779fcb-7544-471e-91e6-ebb4f44bc701" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_f0ee0fec-971d-496c-abe1-80a89caf3e29" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_c927a380-0e94-4ace-a4f6-b1b95c6a7d32" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_f0ee0fec-971d-496c-abe1-80a89caf3e29" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://xbrl.sec.gov/ecd/AwardTypeOnly" xlink:type="simple" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#AwardTypeOnly"/>
  <link:definitionLink xlink:role="http://xbrl.sec.gov/ecd/AwardTypeOnly" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockMember" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:to="loc_us-gaap_RestrictedStockMember" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_swtx_PerformanceStockUnitsMember_3b7637e4-ad55-4c3e-a9a8-9060e261f9bb" xlink:href="swtx-20231231.xsd#swtx_PerformanceStockUnitsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:to="loc_swtx_PerformanceStockUnitsMember_3b7637e4-ad55-4c3e-a9a8-9060e261f9bb" xlink:type="arc" order="6"/>
  </link:definitionLink>
</link:linkbase>
